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Titolo:
EFFECTS OF THE ISOCARBACYCLIN METHYL-ESTER CLINPROST INCORPORATED INTO LIPID MICROSPHERES, IN FOCAL ISCHEMIA OF STROKE-PRONE SPONTANEOUSLY HYPERTENSIVE RATS
Autore:
YAE T; ARAKI H; OOGAMI Y; IWASAKI K; TANABE H; FUJIWARA M;
Indirizzi:
OKAYAMA UNIV,SCH MED,DEPT HOSP PHARM,2-5-1 SHIKATA CHO OKAYAMA 700 JAPAN TAISHO PHARMACEUT CO LTD,RES CTR,DEPT PHARMACOL SAITAMA JAPAN FUKUOKA UNIV,FAC PHARMACEUT SCI,DEPT PHYSIOL FUKUOKA 81401 JAPAN FUKUOKA UNIV,FAC PHARMACEUT SCI,DEPT PHARMACOL FUKUOKA 81401 JAPAN TEIJIN INST BIOMED RES,RES CTR,DEPT PHARMACOL TOKYO JAPAN
Titolo Testata:
Arzneimittel-Forschung
fascicolo: 11, volume: 47, anno: 1997,
pagine: 1200 - 1203
SICI:
0004-4172(1997)47:11<1200:EOTIMC>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL-ISCHEMIA; PROSTACYCLIN ANALOG; BRAIN; DAMAGE; PROSTAGLANDIN-I2; INDOMETHACIN; CIRCULATION; METABOLISM; LESIONS; ARTERY;
Keywords:
CAS 88931-51-5; CLINPROST; FOCAL ISCHEMIA, CEREBRAL; ISOCARBACYCLIN METHYL ESTER, LIPID MICROSPHERES; NOREPINEPHRINE CONTENT, CEREBRAL; TTC-909, IN VIVO STUDIES, PHARMACOLOGY;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
T. Yae et al., "EFFECTS OF THE ISOCARBACYCLIN METHYL-ESTER CLINPROST INCORPORATED INTO LIPID MICROSPHERES, IN FOCAL ISCHEMIA OF STROKE-PRONE SPONTANEOUSLY HYPERTENSIVE RATS", Arzneimittel-Forschung, 47(11), 1997, pp. 1200-1203

Abstract

The effects of TTC-909, the isocarbacyclin methyl ester clinprost (CAS 88931-51-5), incorporated into lipid microspheres, on ischemia-induced decrease in norepinephrine (NE) contents in stroke-prone spontaneously hypertensive rats (SHR-SP) with an occluded middle cerebral aretery (MCA) were examined. Occluding of MCA led to infarction limited to the cerebral cortex and also a severe decrease in NE contents in peripheral regions of the infarction. TTC-909 was injected immediately afterMCA occlusion, and then daily for 6 consecutive days. As TTC-909 in adose of 200 ng/kg significantly (p < 0.05) prevented decreases in NE contents. TTC-909 may have cytoprotective effects on neuronal damage related to ischemia in humans.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/10/20 alle ore 10:16:36