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Titolo:
ABNORMALITY IN PLASMA-CATECHOLAMINES AND MYOCARDIAL ADRENOCEPTORS IN CARDIOMYOPATHIC BIO-53.58 SYRIAN-HAMSTERS AND IMPROVEMENT BY METOPROLOL TREATMENT
Autore:
YAMADA S; OHKURA T; YAMADERA T; ITO O; KIMURA R; NOZAWA Y; HAYASHI S; MIYAKE H;
Indirizzi:
UNIV SHIZUOKA,SCH PHARMACEUT SCI,DEPT BIOPHARM,52-1 YADA SHIZUOKA 422JAPAN TAIHO PHARMACEUT CO LTD,RES LABS PHARMACOL TOKUSHIMA JAPAN TAIHO PHARMACEUT CO LTD,RES LABS DRUG SAFETY TOKUSHIMA JAPAN
Titolo Testata:
The Journal of pharmacology and experimental therapeutics
fascicolo: 3, volume: 283, anno: 1997,
pagine: 1389 - 1395
SICI:
0022-3565(1997)283:3<1389:AIPAMA>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONGESTIVE HEART-FAILURE; PERFORMANCE LIQUID-CHROMATOGRAPHY; CALCIUM-ANTAGONIST RECEPTORS; G-STIMULATORY PROTEIN; BLOOD-BRAIN-BARRIER; DILATED CARDIOMYOPATHY; CARDIAC BETA-1-ADRENOCEPTOR; 6-HYDROXYDOPAMINE TREATMENT; ELECTROCHEMICAL DETECTION; BINDING CHARACTERISTICS;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
S. Yamada et al., "ABNORMALITY IN PLASMA-CATECHOLAMINES AND MYOCARDIAL ADRENOCEPTORS IN CARDIOMYOPATHIC BIO-53.58 SYRIAN-HAMSTERS AND IMPROVEMENT BY METOPROLOL TREATMENT", The Journal of pharmacology and experimental therapeutics, 283(3), 1997, pp. 1389-1395

Abstract

The catecholaminergic neuronal activity and the densities of alpha-i and beta adrenoceptors and angiotensin II receptors were simultaneously determined in BIO 53.58, a model of idiopathic dilated cardiomyopathy, and F1B control hamsters. Further, we examined the effect of repeated p.o. administration of metoprolol on these biochemical parameters. Compared with F1B control hamsters, there was a significant decrease in B-max of specific binding of both (-)-[I-125]iodocyanopindolol and [H-3]prazosin with a marked elevation of plasma catecholamine (mainly norepinephrine and epinephrine) concentrations, in BIO 53.58 hamsters at Ii and 18 weeks of age (severe cardiomyopathic stage), but not at 5 weeks of age. On the other hand, the B-max value of myocardial [I-125]angiotensin II binding in BIO 53.58 hamsters was almost identical to that in F1B hamsters. These results suggest a development of down-regulation of myocardial beta and alpha-i adrenoceptors because of an increased catecholaminergic neuronal activity with aging in BIO 53.58 hamsters. Repeated p.o. administration of a relatively low dose (1 mg/kg/day) of metoprolol for 7 weeks in Ii-week-old BIO 53.58 hamsters caused a significant increase of myocardial (-)-[I-125]iodocyanopindolol binding sites with a marked reduction in plasma catecholamine levels; thisindicated a significant recovery to the F1B levels. The improvement of these biochemical parameters by metoprolol treatment was also accompanied by a significant decrease in the fibrosis in the heart in BIO 53.58 hamsters. These data suggest that catecholaminergic neurons and adrenoceptors play a part in the development of heart failure in idiopathic dilated cardiomyopathy. Consequently, the present study may provide a further pharmacological basis for the use of beta-1 adrenoceptor antagonists in patients with idiopathic dilated cardiomyopathy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 23:36:18