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Titolo:
NOGGIN ACTS DOWNSTREAM OF WNT AND SONIC HEDGEHOG TO ANTAGONIZE BMP4 IN AVIAN SOMITE PATTERNING
Autore:
HIRSINGER E; DUPREZ D; JOUVE C; MALAPERT P; COOKE J; POURQUIE O;
Indirizzi:
INST BIOL DEV MARSEILLE,UMR CNRS 9943,LGPD,CAMPUS DE LUMINY CASE 907 F-13288 MARSEILLE 9 FRANCE INST BIOL DEV MARSEILLE,UMR CNRS 9943,LGPD F-13288 MARSEILLE 9 FRANCE CNRS,INST EMBRYOL CELLULAIRE & MOL F-94736 NOGENT SUR MARNE FRANCE COLL FRANCE F-94736 NOGENT SUR MARNE FRANCE NATL INST MED RES,DIV DEV NEUROBIOL LONDON NW7 1AA ENGLAND
Titolo Testata:
Development
fascicolo: 22, volume: 124, anno: 1997,
pagine: 4605 - 4614
SICI:
0950-1991(1997)124:22<4605:NADOWA>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
BHLH GENE-EXPRESSION; CHICK-EMBRYO; NEURAL-TUBE; SCLEROTOME INDUCTION; POLARIZING ACTIVITY; SPEMANN ORGANIZER; FAMILY MEMBERS; FLOOR PLATE; NOTOCHORD; SIGNALS;
Keywords:
PARAXIAL MESODERM; NEURAL TUBE; LATERAL PLATE; MUSCLE LINEAGES; SOMITE PATTERNING; CHICK; NOGGIN; WNT; SONIC HEDGEHOG;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
48
Recensione:
Indirizzi per estratti:
Citazione:
E. Hirsinger et al., "NOGGIN ACTS DOWNSTREAM OF WNT AND SONIC HEDGEHOG TO ANTAGONIZE BMP4 IN AVIAN SOMITE PATTERNING", Development, 124(22), 1997, pp. 4605-4614

Abstract

In the vertebrate embryo, the lateral compartment of the somite givesrise to muscles of the limb and body wall and is patterned in response to lateral-plate-derived BMP4. Activation of the myogenic program distinctive to the medial somite, i.e. relatively immediate development of the epaxial muscle lineage, requires neutralization of this lateralsignal, We have analyzed the properties of molecules likely to play arole in opposing lateral somite specification by BMP4. We propose that the BMP4 antagonist Noggin plays an important role in promoting medial somite patterning in vivo, We demonstrate that Noggin expression inthe somite is under the control of a neural-tube-derived factor, whose effect can be mimicked experimentally by Wnt1, Wnt1 is appropriatelyexpressed in the neural tube, Furthermore, we show that Sonic Hedgehog is able to activate ectopic expression of Noggin resulting in the blocking of BMP4 specification of the lateral somite, Our results are consistent with a model in which Noggin activation lies downstream of the SHH and Wnt signaling pathways.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 18:56:42