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Titolo:
THE UTILITY OF DEVIANT SIB PAIRS IN THE DETECTION OF LINKAGE
Autore:
ROCHBERG DR; ROCHBERG N; HAMPE CL; SUAREZ BK;
Indirizzi:
WASHINGTON UNIV,SCH MED,DEPT PSYCHIAT,4940 CHILDRENS PL ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DEPT PSYCHIAT ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DEPT GENET ST LOUIS MO 63110 STANFORD UNIV,DEPT HUMAN BIOL STANFORD CA 94305
Titolo Testata:
Genetic epidemiology
fascicolo: 6, volume: 14, anno: 1997,
pagine: 873 - 878
SICI:
0741-0395(1997)14:6<873:TUODSP>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Keywords:
OLIGOGENIC; QUANTITATIVE TRAIT LOCI; SIB PAIR LINKAGE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
5
Recensione:
Indirizzi per estratti:
Citazione:
D.R. Rochberg et al., "THE UTILITY OF DEVIANT SIB PAIRS IN THE DETECTION OF LINKAGE", Genetic epidemiology, 14(6), 1997, pp. 873-878

Abstract

A tripartite sampling design was used to help deduce the genetic structure of a complex biological system. Univariate and multivariate population parameters were estimated from an age/sex stratified sample of unrelated individuals. Estimates of familial resemblance between and within continuous variables were obtained from a sample of randomly ascertained nuclear families. Finally, a sample of highly deviant concordant and discordant independent sib pairs facilitated the discovery of major genes through multipoint linkage analysis. No false positive signals were inferred. The pleiotropic effects of major genes, however, became obscured when linkage analysis was performed on adjusted quantitative variables. (C) 1997 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 17:22:09