Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
A NEW TEST STATISTIC FOR LINKAGE APPLIED TO BIPOLAR DISORDER AND MARKER D18S41
Autore:
CLEVES MA; DAWSON DV; ELSTON RC; SCHNELL AH;
Indirizzi:
CASE WESTERN RESERVE UNIV,DEPT EPIDEMIOL & BIOSTAT,RAMMELKAMP CTR EDUC & RES CLEVELAND OH 44109
Titolo Testata:
Genetic epidemiology
fascicolo: 6, volume: 14, anno: 1997,
pagine: 581 - 586
SICI:
0741-0395(1997)14:6<581:ANTSFL>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Keywords:
AGE OF ONSET; LOD SCORE; RECOMBINATION FRACTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
5
Recensione:
Indirizzi per estratti:
Citazione:
M.A. Cleves et al., "A NEW TEST STATISTIC FOR LINKAGE APPLIED TO BIPOLAR DISORDER AND MARKER D18S41", Genetic epidemiology, 14(6), 1997, pp. 581-586

Abstract

We applied a new test statistic for linkage that removes the traditional assumption of equal female (theta(f)) and male (theta(m)) recombination fractions by testing H-o:theta(f)+theta(m) = 1 vs. H-A:theta(f)+theta(m) < 1 to GAW10 Problem 1. Specifically we reanalyzed the reported possible linkage between a suggested susceptibility locus for bipolar affective disorder and marker D18S41 on chromosome 18 [Stine et al., 1995]. We used penetrance functions fitting the description of thoseused by Stine et al. [1995] assuming a continuous age-dependent logistic distribution. Maximum likelihood marker allele frequencies were estimated assuming Hardy-Weinberg equilibrium. Results from the traditional led-score analyses do not strongly support the existence of linkage between the disease locus and marker D18S41. Similarly, the new teststatistic for linkage failed to provide evidence in support of linkage. This was true whether dominant or recessive models of inheritance were assumed, and whether the analyses included all available pedigreesor were confined to paternally transmitted pedigrees. The appreciabledifference found between our led scores and those obtained by Stine et al. [1995] can be attributed to differences in the assumptions made regarding the age-dependent penetrance function, the marker allele frequencies, or both. (C) 1997 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 09:49:19