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Titolo:
BETA-CAROTENE INHIBITS PERSISTENT AND STIMULATES REMODELING GAMMA-GT-POSITIVE PRENEOPLASTIC LESIONS DURING EARLY PROMOTION OF HEPATOCARCINOGENESIS
Autore:
RIZZI MBSL; DAGLI MLZ; JORDAO AA; PENTEADO MVC; MORENO FS;
Indirizzi:
USP,FAC CIENCIAS FARMACEUT,DEPT ALIMENTOS & NUTR EXPT,BLOCO 14 BR-05508900 SAO PAULO BRAZIL USP,FAC CIENCIAS FARMACEUT,DEPT ALIMENTOS & NUTR EXPT BR-05508900 SAOPAULO BRAZIL UNIV SAO PAULO,FAC VET & ZOOTECHNY,DEPT PATHOL BR-05508900 SAO PAULO BRAZIL
Titolo Testata:
International journal for vitamin and nutrition research
fascicolo: 6, volume: 67, anno: 1997,
pagine: 415 - 422
SICI:
0300-9831(1997)67:6<415:BIPASR>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT-LIVER CARCINOGENESIS; ADENOSYL-L-METHIONINE; HYPERPLASTIC NODULES; TUMOR-FORMATION; ALTERED FOCI; VITAMIN-E; CANCER; GROWTH; 2-ACETYLAMINOFLUORENE; DIETHYLNITROSAMINE;
Keywords:
HEPATOCARCINOGENESIS; PROMOTION; PRENEOPLASTIC LESIONS; BETA-CAROTENE; VITAMIN-A;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
M.B.S.L. Rizzi et al., "BETA-CAROTENE INHIBITS PERSISTENT AND STIMULATES REMODELING GAMMA-GT-POSITIVE PRENEOPLASTIC LESIONS DURING EARLY PROMOTION OF HEPATOCARCINOGENESIS", International journal for vitamin and nutrition research, 67(6), 1997, pp. 415-422

Abstract

The inhibitory effects of beta-carotene or vitamin A on preneoplasticlesions induced in rats were compared, when specifically administeredduring early promotion of hepatocarcinogenesis, Initiation was performed by diethylnitrosamine. During the selection/promotion period 2-acetylaminofluorene was administered and a partial hepatectomy was performed Afterwards, the rats were divided into 3 groups. To two groups, beta-carotene or vitamin A were given for five weeks. Another group sewed as control and received corn oil. At the end of the study, beta-carotene reduced the incidence and total number of hepatocyte nodules, Vitamin A rats exhibited a lower number of nodules, but the incidence was100%, Moreover, beta-carotene reduced the total number of gamma GT-positive preneoplastic lesions, as well as the morphometric parameters of persistent gamma GT-positive lesions, In contrast, morphometric parameters of persistent lesions remained almost unaffected in vitamin A animals, Furthermore, beta-carotene significantly increased the number of remodeling gamma GT-positive preneoplastic lesions. Vitamin A administration, however, resulted only in a small increase in the number ofremodeling lesions. These results suggest that the inhibitory effectsof beta-carotene during early promotion of hepato-carcinogenesis can be attributed not only to an inhibitory effect on persistent lesions, but also to a striking stimulatory activity on remodeling gamma GT-positive lesions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/06/20 alle ore 01:02:31