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Titolo:
DETERMINATION OF CINNARIZINE IN PHARMACEUTICAL PREPARATIONS BY SPECTROPHOTOMETRY, ATOMIC-ABSORPTION SPECTROMETRY AND POTENTIOMETRY
Autore:
HASSAN SSM; ABBAS AB; ELMOSALLAMY MAF;
Indirizzi:
AIN SHAMS UNIV,FAC SCI,DEPT CHEM CAIRO EGYPT ZAGAZIG UNIV,FAC SCI,DEPT CHEM ZAGAZIG EGYPT
Titolo Testata:
Mikrochimica acta
fascicolo: 1-2, volume: 128, anno: 1998,
pagine: 69 - 74
SICI:
0026-3672(1998)128:1-2<69:DOCIPP>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
SELECTIVE DETERMINATION; MEMBRANE-ELECTRODE;
Keywords:
ATOMIC ABSORPTION SPECTROMETRY; SPECTROPHOTOMETRY; POTENTIOMETRY; CINNARIZINE; COBALT TETRATHIOCYANATE COMPLEX; PVC MEMBRANE SENSOR; PHARMACEUTICAL ANALYSIS; ION-SELECTIVE ELECTRODES; DOSAGE FORMS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
S.S.M. Hassan et al., "DETERMINATION OF CINNARIZINE IN PHARMACEUTICAL PREPARATIONS BY SPECTROPHOTOMETRY, ATOMIC-ABSORPTION SPECTROMETRY AND POTENTIOMETRY", Mikrochimica acta, 128(1-2), 1998, pp. 69-74

Abstract

New methods are developed for the determination of cinnarizine in various dosage forms. They are based on the reaction of cinnarizinium cation with cobalt tetrathiocyanate anion, whereby a sparingly soluble blue 2:1 drug: reagent ion-pair complex is quantitatively formed. The complex is (a) extracted with nitrobenzene and spectrophotometrically measured at 622 nm; (b) extracted with nitrobenzene and nebulized in an air-acetylene flame for atomic absorption spectrometric monitoring of cobalt at 242.5 nm; and (c) dispersed in a PVC membrane plasticized with 2-nitrophenyloctyl ether and used as a sensor for direct potentiometric determination of the drug. Optimum reaction conditions and performances of the three analytical techniques are evaluated and compared. At the 25 mg level of cinnarizine, the three methods give results withequal accuracy and precision. The average recovery is 98-99% of the nominal and the mean standard deviation is 0.7%. No significant interferences are caused by drug excipients and diluents.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/11/18 alle ore 04:22:26