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Titolo:
EXERCISE-INDUCED CHANGES IN ENZYMATIC O-METHYLATION OF CATECHOLESTROGENS BY ERYTHROCYTES OF EUMENORRHEIC WOMEN
Autore:
DECREE C; VANKRANENBURG G; GEURTEN P; FUJIMURA Y; KEIZER HA;
Indirizzi:
INST GYNECOENDOCINROL RES,DEPT APPL & EXPT REPROD ENDOCRINOL B-3000 LOUVAIN BELGIUM UNIV MAASTRICHT,FAC HLTH SCI,DEPT MOVEMENT SCI MAASTRICHT NETHERLANDS KYOTO UNIV,DEPT OBSTET & GYNECOL,SAKYO KU KYOTO 606 JAPAN INST GYNECOENDOCINROL RES,DEPT APPL & EXPT REPROD ENDOCRINOL B-3000 LOUVAIN BELGIUM
Titolo Testata:
Medicine and science in sports and exercise
fascicolo: 12, volume: 29, anno: 1997,
pagine: 1580 - 1587
SICI:
0195-9131(1997)29:12<1580:ECIEOO>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
CATECHOL ESTROGENS; METHYLTRANSFERASE ACTIVITY; PHYSICAL EXERCISE; BREAST-CANCER; METABOLISM; INHIBITION; NITECAPONE; HEMODYNAMICS; RESPONSES;
Keywords:
AMENORRHEA; CATECHOLAMINES; CATECHOLESTROGENS; COMT; ESTROGENS; EXERCISE; MENSTRUAL CYCLE; NEUROTRANSMITTERS; NOREPINEPHRINE; WOMEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
C. Decree et al., "EXERCISE-INDUCED CHANGES IN ENZYMATIC O-METHYLATION OF CATECHOLESTROGENS BY ERYTHROCYTES OF EUMENORRHEIC WOMEN", Medicine and science in sports and exercise, 29(12), 1997, pp. 1580-1587

Abstract

The present study was designed to assess the effects of acute exercise and short-term intensive training an calechol-O-methyltransferase (COMT) activity. COMT inactivates catecholamines and converts primary catecholestrogens (CE) into their O-methylated form yielding the 2-(2-MeOE) and 4-methoxyestrogens (4-MeOE). Blood samples were obtained from 15 previously untrained eumenorrheic women (mean +/- SE, (V)over dotO(2max): 43.8 mL.kg(-1).min(-1) +/- 0.6) before and after a 5-d intensive training period, at rest and during incremental exercise. COMT activity was determined in the erythrocytes (RBC COMT) after incubation of blood lysate with primary CE. The formation of both 2- and 4-MeOE was significantly higher (P < 0.05) during the luteal (LPh) than during the follicular phase (FPh). The amount of 2-MeOE formed (FPh: 4.2 +/- 0.2%; LPh: 4.9 +/- 0.2%) was significantly greater than the produced amount of 4-MeOE (FPh: 1.4 +/- 0.1%; LPh: 1.5 +/- 0.1%) (P < 0.05). Both before and after training, incremental exercise did not significantly alter RBC-COMT activity although we observed a trend for RBC-COMT activity increasing proportionally with the exercise intensity. After a brief period of exhaustive training. during rest the formation of 2-MeOE(FPh: +16.7%, LPh: +15.7%) and 4-MeOE (FPh: +28.6%; LPh: +40%) was significantly (P < 0.05) increased. The results of the present study areconsistent with earlier findings reporting increased plasma concentrations of O-methylated CE following training, It is concluded that RBC-COMT activity is increased by brief intensive training, but not by acute exercise. We speculate that an increase in COMT-catalyzed O-methylation of CE may indicate that less COMT is available to deactivate norepinephrine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 07:57:49