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Titolo:
B-50, THE GROWTH-ASSOCIATED PROTEIN-43 - MODULATION OF CELL MORPHOLOGY AND COMMUNICATION IN THE NERVOUS-SYSTEM
Autore:
OESTREICHER AB; DEGRAAN PNE; GISPEN WH; VERHAAGEN J; SCHRAMA LH;
Indirizzi:
UNIV UTRECHT,RUDOLF MAGNUS INST NEUROSCI,DEPT MED PHARMACOL,UNIV WEG 100 NL-3584 CG UTRECHT NETHERLANDS UNIV UTRECHT,RUDOLF MAGNUS INST NEUROSCI,DEPT MED PHARMACOL NL-3584 CG UTRECHT NETHERLANDS UNIV UTRECHT,DEPT PHYSIOL CHEM NL-3584 CG UTRECHT NETHERLANDS NETHERLANDS INST BRAIN RES NL-1105 AZ AMSTERDAM NETHERLANDS
Titolo Testata:
Progress in neurobiology
fascicolo: 6, volume: 53, anno: 1997,
pagine: 627 - 686
SICI:
0301-0082(1997)53:6<627:BTGP-M>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
GAP-43 MESSENGER-RNA; KINASE-C SUBSTRATE; LONG-TERM POTENTIATION; CALMODULIN-BINDING-PROTEIN; RAT SPINAL-CORD; RETINAL GANGLION-CELLS; PRIMARY SENSORY NEURONS; IN-SITU HYBRIDIZATION; AMINO-ACID-SEQUENCE; GENE-RELATED PEPTIDE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
537
Recensione:
Indirizzi per estratti:
Citazione:
A.B. Oestreicher et al., "B-50, THE GROWTH-ASSOCIATED PROTEIN-43 - MODULATION OF CELL MORPHOLOGY AND COMMUNICATION IN THE NERVOUS-SYSTEM", Progress in neurobiology, 53(6), 1997, pp. 627-686

Abstract

The growth-associated protein B-50 (GAP-43) is a presynaptic protein. Its expression is largely restricted to the nervous system, B-50 is frequently used as a marker for sprouting, because it is located in growth cones, maximally expressed during nervous system development and re-induced in injured and regenerating neural tissues. The B-50 gene ishighly conserved during evolution. The B-50 gene contains two promoters and three exons which specify functional domains of the protein. The first exon encoding the 1-10 sequence, harbors the palmitoylation site for attachment to the axolemma and the minimal domain for interaction with G(o) protein. The second exon contains the ''GAP module'', including the calmodulin binding and the protein kinase C phosphorylationdomain which is shared by the family of IQ proteins. Downstream sequences of the second and non-coding sequences in the third exon encode species variability. The third exon also contains a conserved domain for phosphorylation by casein kinase II. Functional interference experiments using antisense oligonucleotides or antibodies, have shown inhibition of neurite outgrowth and neurotransmitter release. Overexpressionof B-50 in cells or transgenic mice results in excessive sprouting. The various interactions, specified by the structural domains, are thought to underlie the role of B-50 in synaptic plasticity, participatingin membrane extension during neuritogenesis, in neurotransmitter release and long-term potentiation. Apparently, B-50 null-mutant mice do not display gross phenotypic changes of the nervous system, although the B-50 deletion affects neuronal pathfinding and reduces postnatal survival. The experimental evidence suggests that neuronal morphology andcommunication are critically modulated by, but not absolutely dependent Bon, (enhanced) B-50 presence. (C) 1997 Elsevier Science Ltd.

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Documento generato il 01/04/20 alle ore 02:21:38