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Titolo:
THE SPECTRUM OF MULTIPLE-MYELOMA - DIAGNOSTIC AND BIOLOGICAL IMPLICATIONS
Autore:
LARSON RS; SUKPANICHNANT S; GREER JP; COUSAR JB; COLLINS RD;
Indirizzi:
UNIV NEW MEXICO,CTR CANC,RM B88A,900 CAMINO SALUD ALBUQUERQUE NM 87131 VANDERBILT UNIV,MED CTR,DEPT PATHOL NASHVILLE TN 37232 VANDERBILT UNIV,MED CTR,DEPT MED NASHVILLE TN 37232 MAHIDOL UNIV,FAC MED,SIRIRAJ HOSP BANGKOK 10700 THAILAND
Titolo Testata:
Human pathology
fascicolo: 12, volume: 28, anno: 1997,
pagine: 1336 - 1347
SICI:
0046-8177(1997)28:12<1336:TSOM-D>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE-MARROW; MORPHOLOGICAL CLASSIFICATION; HISTOLOGIC CLASSIFICATION; IMMUNOBLASTIC LYMPHOMA; SOLITARY PLASMACYTOMA; PROGNOSTIC RELEVANCE; GERMINAL-CENTERS; CELL; LESIONS; AMYLOIDOSIS;
Keywords:
MULTIPLE MYELOMA; HISTOLOGY; PATHOLOGY; IMMUNOHISTOCHEMISTRY; BONE MARROW; PLASMA CELLS;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
53
Recensione:
Indirizzi per estratti:
Citazione:
R.S. Larson et al., "THE SPECTRUM OF MULTIPLE-MYELOMA - DIAGNOSTIC AND BIOLOGICAL IMPLICATIONS", Human pathology, 28(12), 1997, pp. 1336-1347

Abstract

Myeloma is a common and well-studied hematopoietic neoplasm with an impressive spectrum of clinical, laboratory, and histological findings. To enhance our understanding of the diversity of myeloma, including its earliest forms, the clinical and pathological finding in 145 cases of myeloma were documented and analyzed. Our analysis indicated that myeloma has at least two distinct subtypes: one presenting with bone lesions and a nodular growth pattern and the other presenting with anemia and an infiltrative growth pattern. The relationship of these two forms to plasma cell biology is not clear, although both types appear toarise in the marrow. The criteria used in this study identified 85% of cases overall, with a range of 70% to 100%, depending on clinical presentation. Immunoperoxidase studies are required to establish the diagnosis in patients with early marrow involvement. Myeloma in younger patients appears to be clinically and pathologically similar to myelomain older patients. Factors such as dysplasia, immunoglobulin type, orleukemic phase were evenly distributed among clinical presentations and did not apparently identify clinicopathological subtypes of myeloma. Copyright (C) 1997 by W.B. Saunders Company.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 03:14:34