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Titolo:
NONSELECTIVE VERSUS SELECTIVE-INHIBITION OF INDUCIBLE NITRIC-OXIDE SYNTHASE IN EXPERIMENTAL ENDOTOXIC-SHOCK
Autore:
LIAUDET L; ROSSELET A; SCHALLER MD; MARKERT M; PERRET C; FEIHL F;
Indirizzi:
UNIV LAUSANNE HOSP,DEPT INTERNAL MED,SERV B,CRIT CARE DIV CH-1011 LAUSANNE SWITZERLAND UNIV LAUSANNE HOSP,DEPT INTERNAL MED,MED CRIT CARE DIV,INST PATHOPHYSIOL CH-1011 LAUSANNE SWITZERLAND UNIV LAUSANNE HOSP,CENT LAB CLIN CHEM CH-1011 LAUSANNE SWITZERLAND
Titolo Testata:
The Journal of infectious diseases
fascicolo: 1, volume: 177, anno: 1998,
pagine: 127 - 132
SICI:
0022-1899(1998)177:1<127:NVSOIN>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
MULTIPLE ORGAN DYSFUNCTION; SEPTIC SHOCK; IMPROVES SURVIVAL; RODENT MODELS; MICE; AMINOGUANIDINE; SEPSIS; RAT; ATTENUATION; PERITONITIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
L. Liaudet et al., "NONSELECTIVE VERSUS SELECTIVE-INHIBITION OF INDUCIBLE NITRIC-OXIDE SYNTHASE IN EXPERIMENTAL ENDOTOXIC-SHOCK", The Journal of infectious diseases, 177(1), 1998, pp. 127-132

Abstract

The effects of two nitric oxide synthase (NOS) inhibitors with different isoform selectivity were compared in a murine model of endotoxemia. Mice challenged with 70 mg/kg intraperitoneal (ip) lipopolysaccharide (LPS) were treated 6 h after LPS with either N-G-gamma-L-arginine methyl ester (L-NAME, nonselective NOS inhibitor, 10-60 mg/kg), L-canavanine (selective inhibitor of inducible NOS, 50-300 mg/kg), or saline (0.2 mt) given ip, In a subset of mice, plasma concentrations of nitrate (NO breakdown product), lipase (pancreas injury), lactate dehydrogenase, and transaminases (liver injury) were measured 16 h after LPS, Although both inhibitors reduced plasma nitrate, they produced contrasting effects on survival and organ injury. L-NAME enhanced liver damage and tended to accelerate the time of death, while L-canavanine significantly reduced mortality and had no deleterious effects in terms of organ damage. These results indicate that nonselective NOS inhibitors are detrimental in endotoxic shock and support the potential usefulness of selective inducible NOS inhibitors in this setting.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/07/20 alle ore 07:39:57