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Titolo:
PATHOGENESIS OF PARKINSONS-DISEASE
Autore:
SCHAPIRA AHV;
Indirizzi:
ROYAL FREE HOSP,SCH MED,DEPT CLIN NEUROSCI,ROWLAND HILL ST LONDON NW32PF ENGLAND UNIV LONDON,NEUROL INST,DEPT CLIN NEUROL LONDON ENGLAND
Titolo Testata:
Bailliere's clinical neurology
fascicolo: 1, volume: 6, anno: 1997,
pagine: 15 - 36
SICI:
0961-0421(1997)6:1<15:POP>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMPLEX-I DEFICIENCY; MITOCHONDRIAL RESPIRATORY-CHAIN; MAGNETIC-RESONANCE SPECTROSCOPY; HYDROXYLASE GENE POLYMORPHISM; POSITRON EMISSION TOMOGRAPHY; HEREDITARY OPTIC NEUROPATHY; MPTP-INDUCED PARKINSONISM; ELECTRON-TRANSPORT CHAIN; X-RAY-MICROANALYSIS; MONOAMINE OXIDASE-B;
Keywords:
PARKINSONS DISEASE; ENVIRONMENT; DOPAMINERGIC NEURONS; MTDNA; MITOCHONDRIA; FREE RADICALS;
Tipo documento:
Review
Natura:
Periodico
Citazioni:
127
Recensione:
Indirizzi per estratti:
Citazione:
A.H.V. Schapira, "PATHOGENESIS OF PARKINSONS-DISEASE", Bailliere's clinical neurology, 6(1), 1997, pp. 15-36

Abstract

The aetiology and pathogenesis of Parkinson's disease (PD) remain unknown. There is a consensus emerging that there are likely to be multiple aetiologies that may result in the clinical and pathological abnormalities common to the majority of patients with idiopathic PD. Geneticfactors have been suggested as important in either the cause of PD orin determining susceptibility. The recent linkage in one large pedigree of a gene for autosomal dominant parkinsonism to chromosome 4q21-23and the subsequent identification of a mutation in the alpha-synuclein gene of this region are important steps towards identifying a biochemical deficiency capable of causing selective dopaminergic cell death. However, the relevance of such a defect to the majority of patients with apparent sporadic PD remains to be established. Factors that may predispose to substantia nigral cell loss, including mitochondrial dysfunction and oxidative damage, could be common to a number of separate aetiologies. A better understanding of these and their relationship toneuronal loss may provide further clues to aetiology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 11:51:55