Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
USE OF POSITRON-EMISSION-TOMOGRAPHY TO MEASURE THE EFFECTS OF NALMEFENE ON D-1 AND D-2 DOPAMINE-RECEPTORS IN RAT-BRAIN
Autore:
UNTERWALD EM; TSUKADA H; KAKIUCHI T; KOSUGI T; NISHIYAMA S; KREEK MJ;
Indirizzi:
NYU,MED CTR,DEPT PSYCHIAT,550 1ST AVE,HN 512 NEW YORK NY 10016 ROCKEFELLER UNIV,LAB BIOL ADDICT DIS NEW YORK NY 10021 HAMAMATSU PHOTON KK,CENT RES LAB HAMAKITA SHIZUOKA 434 JAPAN
Titolo Testata:
Brain research
fascicolo: 1-2, volume: 775, anno: 1997,
pagine: 183 - 188
SICI:
0006-8993(1997)775:1-2<183:UOPTMT>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
FREELY MOVING RATS; VENTRAL TEGMENTAL AREA; NUCLEUS-ACCUMBENS; ALCOHOL DEPENDENCE; ENDOGENOUS DOPAMINE; LOCOMOTOR-ACTIVITY; MESOLIMBIC SYSTEM; N-METHYLSPIPERONE; OPIATE AGONISTS; H-3 RACLOPRIDE;
Keywords:
PET; IMAGING; OPIOID RECEPTOR ANTAGONIST; RAT BRAIN; DOPAMINE RECEPTOR BINDING; NALMEFENE;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
E.M. Unterwald et al., "USE OF POSITRON-EMISSION-TOMOGRAPHY TO MEASURE THE EFFECTS OF NALMEFENE ON D-1 AND D-2 DOPAMINE-RECEPTORS IN RAT-BRAIN", Brain research, 775(1-2), 1997, pp. 183-188

Abstract

Positron emission tomography (PET) has been used in humans and in non-human primates to image and measure radioligand binding to neuroreceptors, The present study evaluated the feasibility of performing high-resolution PET experiments in a rodent model to measure receptor kinetics, The effects of acute and chronic administration of the opioid antagonist, nalmefene, on the binding activity of [C-11]SCH23390 and [C-11]N-methylspiperone at D-1 and D-2 dopamine receptors, respectively, was investigated in the rat. The interaction between central opioid and dopaminergic systems has been the focus of much attention due to theirinteractive role in mediating reinforcement and locomotor activity. In the present study, adult male Sprague-Dawley rats received either a single injection of 10 mg/kg of nalmefene or control vehicle solution 1 h prior to the PET scan or were chronically administered 10 mg/kg/day of nalmefene or vehicle for 7 days by an osmotic minipump. Followingacute administration of nalmefene, the binding potential of [C-11]SCH23390 in the striatum was significantly increased. No changes in [C-11]N-methylspiperone binding were found. Following chronic nalmefene administration no significant change in either [C-11]SCH23390 binding potential or [11 C]N-methylspiperone binding was detected. These results suggest that nalmefene administration produces transient changes in the binding potential of D-1-receptors in the striatum that are normalized after 1 week of steady-state administration. (C) 1997 Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/20 alle ore 20:09:56