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Titolo:
A CARTILAGE MATRIX DEFICIENCY EXPERIMENTALLY-INDUCED BY VITAMIN-B-6 DEFICIENCY
Autore:
MASSE PG; ZIV I; COLE DEC; MAHUREN JD; DONOVAN SM; YAMAUCHI M; HOWELL DS;
Indirizzi:
UNIV MONCTON,ECOLE NUTR & ETUDES FAMILIALES MONCTON NB E1A 3E9 CANADA SUNY BUFFALO,SCH MED & BIOMED SCI,DEPT ORTHOPAED SURG BUFFALO NY 14260 DEPT VET ADM BUFFALO NY 14214 UNIV TORONTO,DEPT CLIN BIOCHEM TORONTO ON M5G 1L5 CANADA FT WAYNE STATE DEV CTR,DEPT BIOCHEM FT WAYNE IN 46835 UNIV ILLINOIS,DEPT FOOD SCI & HUMAN NUTR URBANA IL 61801 UNIV N CAROLINA,DENT RES CTR CHAPEL HILL NC 27599 VET ADM MED CTR,DEPT MED MIAMI FL 33101 UNIV MIAMI,SCH MED MIAMI FL 33101
Titolo Testata:
Proceedings of the Society for Experimental Biology and Medicine
fascicolo: 1, volume: 217, anno: 1998,
pagine: 97 - 103
SICI:
0037-9727(1998)217:1<97:ACMDEB>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
FACET JOINT CARTILAGE; PHYSICOCHEMICAL CHARACTERISTICS; MOLECULAR PACKING; CONNECTIVE-TISSUE; INORGANIC SULFATE; IGF-I; COLLAGEN; HOMOCYSTEINE; CHICKS; OSTEOARTHRITIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
P.G. Masse et al., "A CARTILAGE MATRIX DEFICIENCY EXPERIMENTALLY-INDUCED BY VITAMIN-B-6 DEFICIENCY", Proceedings of the Society for Experimental Biology and Medicine, 217(1), 1998, pp. 97-103

Abstract

A vitamin B-6-deficiency-induced disorder in avian articular cartilage resembling osteoarthritis has been further characterized. We measured several parameters of proteoglycan (PG) metabolism, i.e., fixed charge density and sulfated glycosaminoglycans (S-GAG) content in PN-deficient versus control articular cartilage and synovial fluid from the knee joint. Statistically significant changes were: 1) decreased contentand increased extractability of total sulfated PGs from articular cartilage with guanidine HCl; 2) elevation of S-GAG concentration in synovial fluid; 3) increased plasma cystathionine (sulfur amino acid) levels, Pc synthesis as assessed by (SO4)-S-35 incorporation into S-GAGs was not impaired. A lack of cartilage swelling in 0.15 M saline and thenormal water content indicated that although disturbed, the collagen network was not disrupted. This finding was in agreement with a previous microscopic study that revealed no fissures in the articular cartilage. Previous findings of a normal aggregating Pc size-distribution and absence of elevated metalloproteases made a disturbance of aggregating PG metabolism unlikely. Escape into the synovial fluid of small PGs, normally bound to articular collagen, was believed to result from analteration in collagen molecular organization that could be secondaryto elevated circulating SH-compounds.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 06:58:48