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Titolo:
PRELIMINARY INVESTIGATIONS ON ANDROGEN RECEPTOR GENE-MUTATIONS IN INFERTILE MEN
Autore:
TINCELLO DG; SAUNDERS PTK; HARGREAVE TB;
Indirizzi:
LIVERPOOL WOMENS HOSP,DEPT UROGYNAECOL LIVERPOOL L8 7SS MERSEYSIDE ENGLAND UNIV EDINBURGH,WESTERN GEN HOSP,DEPT SURG EDINBURGH EH4 2XU MIDLOTHIAN SCOTLAND MRC,CTR REPROD BIOL,REPROD BIOL UNIT EDINBURGH EH3 9EW MIDLOTHIAN SCOTLAND
Titolo Testata:
Molecular human reproduction
fascicolo: 11, volume: 3, anno: 1997,
pagine: 941 - 943
SICI:
1360-9947(1997)3:11<941:PIOARG>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
GRADIENT GEL-ELECTROPHORESIS; SINGLE-BASE CHANGES; DNA FRAGMENTS; GC-CLAMP; INSENSITIVITY; RESISTANCE;
Keywords:
ANDROGEN; INFERTILITY; MUTATION; OLIGOZOOSPERMIA; RECEPTOR;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
D.G. Tincello et al., "PRELIMINARY INVESTIGATIONS ON ANDROGEN RECEPTOR GENE-MUTATIONS IN INFERTILE MEN", Molecular human reproduction, 3(11), 1997, pp. 941-943

Abstract

A total of 50 men were selected from all patients attending an infertility clinic on the basis of oligozoospermia or azoospermia with concentrations of luteinizing hormone >6 IU/l and testosterone >30 nmol/l. Six of these men responded to written invitation and DNA was extractedfrom blood leukocytes. Individual exons of the androgen receptor genewere amplified by polymerase chain reaction and screened for the presence of mutations by denaturing gradient gel electrophoresis. The glutamine rich portion of exon 1 was sequenced directly. All of the codingsequence of the gene was examined except the glycine rich portion of exon 1 in all patients. No mutations or deletions were identified. Androgen receptor gene mutations do not appear to be present in infertilemen with biochemical disturbances compatible with androgen resistance. It is therefore unlikely that such mutations are a major factor in the pathogenesis of oligozoospermia/azoospermia and infertility.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 04:28:54