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Titolo:
THYMOPENTIN LOADED MICROSPHERE PREPARATION BY W O/W EMULSION TECHNIQUE - IN-VITRO EX-VIVO EVALUATION/
Autore:
CONTI B; PANICO AM; VENTURA CA; GIUNCHEDI P; PUGLISI G;
Indirizzi:
UNIV CATANIA,IST CHIM FARMACEUT,VA DORIA I-95125 CATANIA ITALY UNIV PAVIA,DIPARTIMENTO CHIM FARMACEUT I-27100 PAVIA ITALY
Titolo Testata:
Journal of microencapsulation
fascicolo: 3, volume: 14, anno: 1997,
pagine: 303 - 310
SICI:
0265-2048(1997)14:3<303:TLMPBW>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYLACTIC ACID; STABILITY; ACETATE;
Keywords:
MICROSPHERES; POLY(LACTIDE); W/O/W EMULSION; POLY(LACTIDE-CO-GLYCOLIDE); THYMOPENTIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
10
Recensione:
Indirizzi per estratti:
Citazione:
B. Conti et al., "THYMOPENTIN LOADED MICROSPHERE PREPARATION BY W O/W EMULSION TECHNIQUE - IN-VITRO EX-VIVO EVALUATION/", Journal of microencapsulation, 14(3), 1997, pp. 303-310

Abstract

Poly-D,L-lactide (PDLLA) and polylactide-co-glycolide (PLGA) microspheres containing thymopentin have been prepared by a water-in-oil-in-water-emulsion/solvent evaporation technique. The goal is to stabilize the active compound thymopentin, and to prolong its therapeutic activity, by embedding the drug in a polymeric matrix. The microspheres obtained have been characterized for their morphology and drug content. In-vitro dissolution tests have been performed on the microspheres. Results show that the type of polymer employed (PDLLA or PLGA) does not seem to affect microsphere morphology, while in-vitro dissolution profiles are greatly influenced by the composition of polymer matrix. Ex-vivoevaluation of PLGA microspheres performed on mouse thymocites shows that biological activity of Thymopentin is maintained after loading into PLGA microspheres.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 03:56:57