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Titolo:
TIME-DEPENDENT SENSITIZATION - POSSIBLE IMPLICATIONS FOR CLINICAL PSYCHOPHARMACOLOGY
Autore:
ANTELMAN SM; SOARES JC; GERSHON S;
Indirizzi:
UNIV PITTSBURGH,SCH MED,WESTERN PSYCHIAT INST & CLIN,DEPT PSYCHIAT,3811 OHARA ST PITTSBURGH PA 15213
Titolo Testata:
Behavioural pharmacology
fascicolo: 6-7, volume: 8, anno: 1997,
pagine: 505 - 514
SICI:
0955-8810(1997)8:6-7<505:TS-PIF>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHEMICAL ODOR INTOLERANCE; ELECTROCONVULSIVE-THERAPY; STRIATAL DOPAMINE; BETA-ENDORPHIN; YOUNG-ADULTS; STRESS; AMPHETAMINE; SUBSENSITIVITY; CLOMIPRAMINE; DISORDER;
Keywords:
ANTIDEPRESSANTS; MECHANISMS OF ACTION; NEUROPHARMACOLOGY; PSYCHOPHARMACOLOGY; PSYCHOTROPIC AGENTS; THERAPEUTICS; TIME-DEPENDENT SENSITIZATION;
Tipo documento:
Review
Natura:
Periodico
Citazioni:
62
Recensione:
Indirizzi per estratti:
Citazione:
S.M. Antelman et al., "TIME-DEPENDENT SENSITIZATION - POSSIBLE IMPLICATIONS FOR CLINICAL PSYCHOPHARMACOLOGY", Behavioural pharmacology, 8(6-7), 1997, pp. 505-514

Abstract

Time-dependent sensitization (TDS) has been described in animal models over the past 20 years. It is a phenomenon that occurs in a variety of biological systems, and corresponds to the cellular and systems response to a foreign or stressful stimulus. The exposure to the stimulustriggers the responses typical of that particular biological system, which are progressively amplified with time. This phenomenon has potential major implications for clinical pharmacology. Some human studies have investigated this phenomenon to date. Antidepressant action, withits typical lag in the onset of effects, may be a fruitful paradigm to understand the relevance of TDS for psychopharmacological treatment. In this paper we review these emerging findings, and suggest that clinical pharmacology research should investigate this process further inexpanded human studies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/21 alle ore 00:46:55