Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
REQUIREMENT FOR THE RYANODINE RECEPTOR-TYPE 3 FOR EFFICIENT CONTRACTION IN NEONATAL SKELETAL-MUSCLES
Autore:
BERTOCCHINI F; OVITT CE; CONTI A; BARONE V; SCHOLER HR; BOTTINELLI R; REGGIANI C; SORRENTINO V;
Indirizzi:
SAN RAFFAELE SCI INST,DIBIT I-20132 MILAN ITALY SAN RAFFAELE SCI INST,DIBIT I-20132 MILAN ITALY EUROPEAN MOL BIOL LAB HEIDELBERG GERMANY UNIV PAVIA,INST HUMAN PHYSIOL I-27100 PAVIA ITALY UNIV SIENA,INST HISTOL I-53100 SIENA ITALY
Titolo Testata:
EMBO journal
fascicolo: 23, volume: 16, anno: 1997,
pagine: 6956 - 6963
SICI:
0261-4189(1997)16:23<6956:RFTRR3>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYCLIC ADP-RIBOSE; MICE LACKING; CA2+ RELEASE; SARCOPLASMIC-RETICULUM; POSTNATAL-DEVELOPMENT; ALPHA-RYANODINE; CALCIUM; CHANNEL; ISOFORMS; RYR3;
Keywords:
CA2+ RELEASE CHANNELS; MUSCLE CONTRACTION; MUSCLE DEVELOPMENT; RYANODINE RECEPTORS;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
F. Bertocchini et al., "REQUIREMENT FOR THE RYANODINE RECEPTOR-TYPE 3 FOR EFFICIENT CONTRACTION IN NEONATAL SKELETAL-MUSCLES", EMBO journal, 16(23), 1997, pp. 6956-6963

Abstract

The skeletal isoform of Ca2+ release channel, RyR1, plays a central role in activation of skeletal muscle contraction, Another isoform, RyR3, has been observed recently in some mammalian skeletal muscles, but whether it participates in regulating skeletal muscle contraction is not known, The expression of RyR3 in skeletal muscles was studied in mice from late fetal stages to adult life, RyR3 was found to be expressed widely in murine skeletal muscles during the post-natal phase of muscle development, but was not detectable in muscles of adult mice, withthe exception of the diaphragm and soleus muscles, RyR3 knockout micewere generated, and it was shown that skeletal muscle contraction in these mice was impaired during the first weeks after birth, In skeletal muscles isolated from newborn RyR3(-/-) mice, hut not in those from adult mice, the twitch elicited by electrical stimulation and the contracture induced by caffeine were strongly depressed, These results provide the first evidence that RyR3 has a physiological role in excitation-contraction coupling of neonatal skeletal muscles, The disproportion between the low amount of RyR3 and the large impact of the RyR3 knockout suggests that this isoform contributes to the amplification of Ca2+ released by the existing population of ryanodine receptors (RyR1).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 04:37:42