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Titolo:
EFFICACY AND SAFETY OF LAMIVUDINE ON REPLICATION OF RECURRENT HEPATITIS-B AFTER CADAVERIC RENAL-TRANSPLANTATION
Autore:
ROSTAING L; HENRY S; CISTERNE JM; DUFFAUT M; ICART J; DURAND D;
Indirizzi:
CHU RANGUEIL,SERV NEPHROL,1 AVE JEAN POULHES F-31054 TOULOUSE FRANCE TOULOUSE UNIV HOSP,VIROL LAB,MULTIORGAN TRANSPLANT UNIT TOULOUSE FRANCE TOULOUSE UNIV HOSP,DEPT INTERNAL MED TOULOUSE FRANCE
Titolo Testata:
Transplantation
fascicolo: 11, volume: 64, anno: 1997,
pagine: 1624 - 1627
SICI:
0041-1337(1997)64:11<1624:EASOLO>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
SURFACE-ANTIGEN; LIVER-DISEASE; ASYMPTOMATIC CARRIERS; ALLOGRAFT RECIPIENTS; INFECTION; THERAPY; FAILURE; ALPHA; VIRUS;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
L. Rostaing et al., "EFFICACY AND SAFETY OF LAMIVUDINE ON REPLICATION OF RECURRENT HEPATITIS-B AFTER CADAVERIC RENAL-TRANSPLANTATION", Transplantation, 64(11), 1997, pp. 1624-1627

Abstract

Background. The aim of this pilot study was to evaluate the efficacy and the safety of lamivudine therapy in hepatitis B virus (HBV)-positive/DNA-positive renal transplant recipients, Methods. Six HBV DNA-positive cadaveric renal transplant recipients ranging in age from 49+/-6 years were administered lamivudine, at 100 mg/day for a period of at least 6 months, on a compassionate-use basis, Lamivudine is the (-) enantiomer of 3'-thiacytidine, which is known to be a potent inhibitor ofHBV replication, All of the patients but one were on cyclosporine-based immunosuppression. Results. The mean serum creatinine was 134+/-44 mu mol/L. The mean duration of HBV infection was 230+/-54 months (156-288). All of the patients but one had high serum alanine aminotransferase levels (122+/-52 IU/L; range, 45-243). Histological evaluation showed the presence of either chronic active hepatitis (n=4) or cirrhosis(n=2). All of the patients but one were hepatitis B e antigen negative/hepatitis B e antibody positive, but none were coinfected with either hepatitis C virus or hepatitis D virus. Conclusions. Lamivudine therapy was associated with (i) a normalization of alanine aminotransferase levels in four of five patients when these levels were increased at the beginning (n=5); (ii) a rapid disappearance of HBV DNA from the serum (detected by hybridization) in all of the patients; (iii) the negativity of HBV DNA by polymerase chain reaction in four patients; and (iv) no change in renal function and in proteinuria when present (one patient), Finally, no adverse effects were noted. When lamivudine therapy was stopped for four patients after 6 months, it was associated with a biochemical and virological relapse within the weeks that followed. Lamivudine therapy was therefore resumed for these patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 20:05:36