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Titolo:
MITOGENS AS MOTOGENS
Autore:
CHICOINE MR; SILBERGELD DL;
Indirizzi:
WASHINGTON UNIV,SCH MED,DEPT NEUROL SURG,CAMPUS BOX 8057,660 S EUCLIDAVE ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DEPT NEUROL SURG ST LOUIS MO 63110
Titolo Testata:
Journal of neuro-oncology
fascicolo: 3, volume: 35, anno: 1997,
pagine: 249 - 257
SICI:
0167-594X(1997)35:3<249:>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPIDERMAL GROWTH-FACTOR; HUMAN GLIOMA-CELLS; HUMAN GLIOBLASTOMA-MULTIFORME; MALIGNANT HUMAN GLIOMAS; BRAIN-TUMOR BIOPSIES; FACTOR RECEPTOR GENE; RAT-BRAIN; IN-VITRO; TRANSFORMED-CELLS; INVITRO;
Keywords:
BRAIN TUMOR; CELL CULTURE; CELL LOCOMOTION; GLIOMA; CYTOKINES; MITOGENS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
72
Recensione:
Indirizzi per estratti:
Citazione:
M.R. Chicoine e D.L. Silbergeld, "MITOGENS AS MOTOGENS", Journal of neuro-oncology, 35(3), 1997, pp. 249-257

Abstract

Numerous in vivo methodologies have documented the invasive behavior of glioma cells through normal brain parenchyma. Glioma cell locomotion has also been assessed with a number of in vitro assays including the Boyden chamber and other chemotaxis assays, colloidal gold cell tracking analysis of migration of cells tumor cells from spheroids, confrontation cultures of glioma cells with aggregates of non-neoplastic tissue, time-lapse video microscopy, electron microscopic examination of the cytomorphologic correlates of cell motility, the radial dish assay, and quantitative enzyme immunoassay of proteins associated with invasion (e.g. laminin). Several of these techniques have been specifically modified to assess the effects of cytokines on glioma cell motility in vitro. Cytokines studied utilizing these methods include: epidermalgrowth factor (EGF), basic fibroblast growth factor (bFGF), the bb dimer of platelet-derived growth factor (PDGFbb), nerve growth factor (NGF), interleukin 2 (IL-2), transforming growth factors alpha and beta 1 (TGF alpha and TGFstraat(1)), and tumor necrosis factor alpha (TNF alpha). This review summarizes the investigational methods used to evaluate random and directional glioma cell motility and invasion in vivo and in vitro. The roles of specific mitogens as motogens, as evaluatedwith these methods are then presented.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 19:56:32