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Titolo:
INDEPENDENT INTERACTION OF ALPRAZOLAM AND CAFFEINE UNDER CHRONIC DOSEREGIMENS ON DIFFERENTIAL REINFORCEMENT OF LOW-RATE (DRL 45-S) PERFORMANCE
Autore:
LAU CE; WANG YX; FALK JL;
Indirizzi:
RUTGERS STATE UNIV,DEPT PSYCHOL,BUSCH CAMPUS NEW BRUNSWICK NJ 08903
Titolo Testata:
Psychopharmacology
fascicolo: 3, volume: 134, anno: 1997,
pagine: 277 - 286
Fonte:
ISI
Lingua:
ENG
Soggetto:
DISCRIMINATIVE MOTOR CONTROL; LOCOMOTOR-ACTIVITY; SQUIRREL-MONKEYS; RESPONSE CURVES; IP CAFFEINE; TIME-COURSE; MIDAZOLAM; DIAZEPAM; TOLERANCE; PHARMACOKINETICS;
Keywords:
ALPRAZOLAM; BENZODIAZEPINE; CAFFEINE; CROSS TOLERANCE; DRL; DRUG INTERACTION; METHYLXANTHINE; PHARMACOKINETICS; TOLERANCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
50
Recensione:
Indirizzi per estratti:
Citazione:
C.E. Lau et al., "INDEPENDENT INTERACTION OF ALPRAZOLAM AND CAFFEINE UNDER CHRONIC DOSEREGIMENS ON DIFFERENTIAL REINFORCEMENT OF LOW-RATE (DRL 45-S) PERFORMANCE", Psychopharmacology, 134(3), 1997, pp. 277-286

Abstract

In previous research, we found an independent interaction of alprazolam and caffeine in rats under acute dose regimens using two measures (reinforcement rate and shorter-response rate) of a differential reinforcement of low rate performance (DRL 45-s) in 3-h sessions. Applying the same behavioral endpoints, the present study investigated the alprazolam-caffeine interaction under chronic dose regimens. Both drugs were administered by the oral route. Acute alprazolam and caffeine dose-response curves (DRCs) were characterized and were then used to determine the maintenance dose for the respective chronic dose regimens. Bothdrugs decreased the reinforcement rate and increased the shorter-response rate in a dose-related fashion. An alprazolam DRC also was determined during chronic-caffeine, chronic-alprazolam, and concurrent chronic-caffeine-alprazolam dose regimens. Complete tolerance to caffeine-induced rate changes was observed on the second day. Incomplete tolerance occurred only at higher alprazolam doses (7-12.5 mg/kg). Cross tolerance was not found between alprazolam and caffeine. Upon discontinuation of both drugs, performance progressively returned to base line. The four alprazolam DRCs as well as the effect-time profiles demonstrated that caffeine altered neither the magnitudes nor the patterns of alprazolam effects on the two rates under chronic dose regimens. The PochDRC method further confirmed the independent interaction of alprazolam and caffeine. Thus, the independence of the interaction held for both the acute and chronic dose regimens despite the development of tolerance in the latter regimens.

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Documento generato il 02/04/20 alle ore 02:32:20