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Titolo:
DOPAMINE-RECEPTOR AGONISTS ALTER GAP PRESTIMULUS MODULATION
Autore:
LEITNER DS; GIRTEN EM;
Indirizzi:
ST JOSEPHS UNIV,DEPT PSYCHOL,5600 CITY AVE PHILADELPHIA PA 19131
Titolo Testata:
Psychopharmacology
fascicolo: 3, volume: 134, anno: 1997,
pagine: 213 - 220
Fonte:
ISI
Lingua:
ENG
Soggetto:
INFORMATION-PROCESSING DEFICITS; ACOUSTIC STARTLE REFLEX; PREPULSE INHIBITION; D-AMPHETAMINE; ANIMAL-MODEL; SCHIZOPHRENIA; RATS; QUINPIROLE; APOMORPHINE; HABITUATION;
Keywords:
ATTENTION; DOPAMINE; GAP DETECTION; PREPULSE INHIBITION; QUINPIROLE; SCHIZOPHRENIA; SENSORY PROCESSING; SKF-38393; STARTLE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
D.S. Leitner e E.M. Girten, "DOPAMINE-RECEPTOR AGONISTS ALTER GAP PRESTIMULUS MODULATION", Psychopharmacology, 134(3), 1997, pp. 213-220

Abstract

An innocuous sensory event (a prestimulus) that briefly precedes a startle-eliciting stimulus (SES) will reduce the amplitude of the subsequently elicited reflex. In three experiments brief silent periods in otherwise continuous noise (gaps) were used as prestimuli to investigate the effects of the D-1 dopamine receptor agonist (+/-)-SKF-38393 (SKF) and the dopamine D-2 receptor group agonist (-)-quinpirole hydrochloride on gap inhibition of the rat's acoustic startle reflex. Gap durations of 4 and 50 ms were analyzed. Quinpirole (0-1.6 mg/kg) had a biphasic effect on gap inhibition. Lower doses increased gap inhibition, an effect that peaked at the 0.4 mg/kg dose. For higher doses, inhibition returned to control levels for the 4-ms long gap, but remained elevated for the 50-ms long gap. SKF had no effect on gap inhibition, andhaloperidol (0.2 mg/kg) reversed the quinpirole-induced increase of gap inhibition. These data implicate the D-2 dopamine receptor group ingap inhibition of startle modulation. The results are discussed in terms of the effects of catecholamine agonists on attention.

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Documento generato il 26/01/20 alle ore 01:18:11