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Titolo:
MODULATION OF ANTIOXIDANT ENZYMES IN BLEOMYCIN-TREATED RATS BY VITAMIN-C AND BETA-CAROTENE
Autore:
DESAI VG; LYNCOOK LE; AIDOO A; CASCIANO DA; FEUERS RJ;
Indirizzi:
US FDA,DIV GENET TOXICOL,NATL CTR TOXICOL RES,US DEPT HHS,HFT-120,3900 NCTR RD JEFFERSON AR 72079 US FDA,DIV GENET TOXICOL,NATL CTR TOXICOL RES,US DEPT HHS JEFFERSON AR 72079
Titolo Testata:
Nutrition and cancer
fascicolo: 2, volume: 29, anno: 1997,
pagine: 127 - 132
SICI:
0163-5581(1997)29:2<127:MOAEIB>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-BLOOD PLASMA; SUPEROXIDE-DISMUTASE; METABOLIZING-ENZYMES; HYDROXYL RADICALS; ASCORBIC-ACID; CANTHAXANTHIN; GENOTOXICITY; GLUTATHIONE; PEROXIDASE; CANCER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
V.G. Desai et al., "MODULATION OF ANTIOXIDANT ENZYMES IN BLEOMYCIN-TREATED RATS BY VITAMIN-C AND BETA-CAROTENE", Nutrition and cancer, 29(2), 1997, pp. 127-132

Abstract

Bleomycin (BLM), an antineoplastic drug, is known to induce DNA strand breaks and is also mutagenic in mammalian cells, however, its mechanism of action is not well understood. It has been proposed that BLM cytotoxicity is mediated through the generation of reactive oxygen species. We have determined the effects of BLM on endogenous hepatic antioxidant enzymes such as glutathione peroxidase (GPx), glutathione reductase, and glucose-6-phosphate dehydrogenase in rats exposed to BLM in conjunction with dietary vitamins, vitamin C and beta-carotene (BC). Male Fischer 344 rats of two different age groups were treated with BLM in the presence or absence of antioxidant vitamins. In control animals, an age-associated decrease in GPx activity was noted (p < 0.05). Thedecrease in GPx activity observed in BLM-treated old animals given vitamin C was significant (p < 0.05) compared with BLM-treated young animals fed vitamin C. BC moderately induced GPx and glutathione reductase activities in old BLM-treated animals; however the increase in GPx was statistically significant (p < 0.05) only compared with old controls. A similar increase was noted in the activities of all the enzymes examined in young animals. Our results indicate that BLM exposure was accompanied by alterations in the activities of endogenous antioxidant enzymes, with a profound increase in activities occurring in old animals. In addition, the observed enzyme activities were modulated by antioxidant vitamin administration. The observation that both vitamins displayed differential effects on the enzyme activities also suggests that vitamin C and BC exert their effects by separate mechanisms.

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Documento generato il 07/04/20 alle ore 03:51:02