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Titolo:
TELOMERASE ACTIVITY AND SURVIVAL OF PATIENTS WITH NODE-POSITIVE BREAST-CANCER
Autore:
CLARK GM; OSBORNE CK; LEVITT D; WU F; KIM NW;
Indirizzi:
UNIV TEXAS,HLTH SCI CTR,DEPT MED,DIV MED ONCOL,7703 FLOYD CURL DR SANANTONIO TX 78284 GERON CORP MENLO PK CA 00000
Titolo Testata:
Journal of the National Cancer Institute
fascicolo: 24, volume: 89, anno: 1997,
pagine: 1874 - 1881
Fonte:
ISI
Lingua:
ENG
Soggetto:
TERMINAL TRANSFERASE; PROGNOSTIC FACTORS; HUMAN-LYMPHOCYTES; IMMORTAL CELLS; DNA; RIBONUCLEOPROTEIN; TETRAHYMENA; CARCINOMA; SPECIMENS; RECEPTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
G.M. Clark et al., "TELOMERASE ACTIVITY AND SURVIVAL OF PATIENTS WITH NODE-POSITIVE BREAST-CANCER", Journal of the National Cancer Institute, 89(24), 1997, pp. 1874-1881

Abstract

Background: Shortening of telomeres (specialized structures at the ends of chromosomes) beyond a certain length may signal a cell to stop dividing and to enter senescence. A ribonucleoprotein enzyme, telomerase, is a key component in maintaining telomere length, Because the majority of cancers express telomerase but most normal somatic tissues do not, we measured the level of telomerase expression in primary breast cancer specimens for correlation with traditional prognostic indicators and disease outcome. Methods: Telomerase activity was measured in frozen human breast cancer specimens by use of the Telomeric Repeat Amplification Protocol (TRAP) assay, The level of telomerase activity was expressed as total product generated (TPG) and was corrected for specimen cellularity by expressing it as a ratio of TPG to the sample's 28Sribosomal RNA content Results: A preliminary study of 150 breast cancer specimens demonstrated that telomerase activity correlated with thefraction of cells in S phase of the cell cycle (r(sp) = .23), Zn a larger prognostic study of 398 tumors from patients with lymph node-positive breast cancer, telomerase expression correlated with S-phase fraction, progesterone receptor level, DNA ploidy, and lymph node status. After correcting for sample cellularity, increasing TPG levels were associated with decreased disease-free survival (P = .041) and overall survival (P = .009) of the patients, The telomerase activity level remained strongly predictive of death (P = .027) and marginally predictiveof disease recurrence (P = .08) after adjustment for other prognosticfactors, All P values are two-sided, Conclusions: Telomerase activityin human breast cancers is associated with a more aggressive tumor phenotype in patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 10:39:39