Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
RENAL BRUSH-BORDER SODIUM-SULFATE COTRANSPORT IN GUINEA-PIG - EFFECT OF AGE AND DIET
Autore:
PENA DR; NEIBERGER RE;
Indirizzi:
UNIV FLORIDA,COLL MED,DEPT PEDIAT,JHMHC,PO 100296 GAINESVILLE FL 32610 UNIV FLORIDA,COLL MED,DEPT PEDIAT,JHMHC GAINESVILLE FL 32610
Titolo Testata:
Pediatric nephrology
fascicolo: 6, volume: 11, anno: 1997,
pagine: 724 - 727
SICI:
0931-041X(1997)11:6<724:RBSCIG>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEMBRANE-VESICLES; TRANSPORT KINETICS; RAT-KIDNEY; D-GLUCOSE; REABSORPTION; PHOSPHATE; CELLS;
Keywords:
SULFATE; BRUSH BORDER; TRANSPORT; ADAPTATION; DEVELOPMENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
D.R. Pena e R.E. Neiberger, "RENAL BRUSH-BORDER SODIUM-SULFATE COTRANSPORT IN GUINEA-PIG - EFFECT OF AGE AND DIET", Pediatric nephrology, 11(6), 1997, pp. 724-727

Abstract

Renal adaptation to changes in inorganic sulfate intake and acre was studied by comparing sulfate uptake by proximal tubule brush border membrane vesicles (BBMV) from guinea pigs of different ages on relatively high-or low-sulfate diets. Adult (> 60 days) or young guinea pigs (<25 days) were fed either a control diet (0.25% sulfur content), a sulfur-free diet, or a high-sulfate diet. After 5 days on the diet, BBMV were obtained and kinetic analysis of (35)sulfate uptake was determined. In adult guinea pigs, the low-sulfate diet produced a significant increase in apparent maximal velocity (V-max). In young guinea pigs, a lower sulfate intake did not appreciably increase V-max, but a high-sulfate intake produced a reduction in V-max. The affinity for sulfate (K-m) was not changed in either age group. The dietary sulfate intake did not alter sodium gradient dependent-D-glucose or (32)phosphate V-max. In conclusion, our data indicate that renal inorganic sulfate BBMV uptake is regulated and responds to conditions of increased need (i.e., during the growth phase in young animals and during periods of decreased sulfate availability in adult animals) by increasing BBMV V-max.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/21 alle ore 18:20:48