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Titolo:
THE ETIOLOGIC ASPECTS OF REACTIVE HEMOPHA GOCYTIC PROCESS - A RETROSPECTIVE STUDY IN 99 PATIENTS
Autore:
SAILLER L; DUCHAYNE E; MARCHOU B; BROUSSET P; PRIS J; MASSIP P; CORBERAND J; ARLET P;
Indirizzi:
CHU RANGUEIL,SERV MED INTERNE B,CHEMIN VALLON F-31054 TOULOUSE FRANCE
Titolo Testata:
La Revue de medecine interne
fascicolo: 11, volume: 18, anno: 1997,
pagine: 855 - 864
SICI:
0248-8663(1997)18:11<855:TEAORH>2.0.ZU;2-1
Fonte:
ISI
Lingua:
FRE
Soggetto:
EPSTEIN-BARR-VIRUS; T-CELL LYMPHOMA; IMMUNE-DEFICIENCY SYNDROME; MIMICKING MALIGNANT HISTIOCYTOSIS; MACROPHAGE ACTIVATION SYNDROME; VISCERAL LEISHMANIASIS; MILIARY TUBERCULOSIS; HIV-INFECTION; PANCYTOPENIA; BRUCELLOSIS;
Keywords:
HEMOPHAGOCYTIC PROCESS; HEMOPHAGOCYTIC SYNDROME; ETIOLOGY; LYMPHOMA; ACQUIRED IMMUNE DEFICIENCY SYNDROME;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
92
Recensione:
Indirizzi per estratti:
Citazione:
L. Sailler et al., "THE ETIOLOGIC ASPECTS OF REACTIVE HEMOPHA GOCYTIC PROCESS - A RETROSPECTIVE STUDY IN 99 PATIENTS", La Revue de medecine interne, 18(11), 1997, pp. 855-864

Abstract

We describe the causes of reactive hemophagocytic process in a retrospective study including 99 patients. The main diagnosis were: lymphomas (18 cases), pyogenic bacteria infections (15 cases), herpes virus infections (12 cases), other infections (multiple, parasitic, fungal, mycobacterial, unidentified) (11 cases), acute hepatitis (five cases), systemic lupus erythematosus (three cases). We also found numerous other diseases involving the reticuloendothelial system. The cause remained undetermined in 16 cases. Lymphoma accounted for 64% of the cases inpreviously healthy patients who had been febrile for more than 10 days at the time of the diagnosis of reactive hemophagocytic process, andfor 31% in HIV-positive patients. Lymphomas were rare (5%) in non HIV-positive, immunosuppressed patients. In this setting and in previously healthy patients who had been febrile for less than 10 days, infectious diseases were widely dominant (respectively 60% and 86% of the cases). Those were mainly due to pyogenic bacteria and to herpes virus. Arapidly fatal evolution occured in some cases of lymphomas-related hemophagocytic process. These data support the choice of agressive investigations in order to diagnose lymphoma in previously healthy patientspresenting with reactive hemophagocytic process who have been febrilefor more than 10 days, and in selected HN-patients. Such a procedure is not recommended in the other cases.

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Documento generato il 02/12/20 alle ore 05:19:19