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Titolo:
HUMORAL IMMUNE-RESPONSE WITHIN THE LUNG IN HIV-1 INFECTION
Autore:
MOJA P; JALIL A; QUESNEL A; PEROL M; COTTE L; LIVROZET JM; BOIBIEUX A; CHAMSON A; VERGNON JM; LUCHT F; TRAN R; POZZETTO B; GENIN C;
Indirizzi:
FAC MED,LAB RECH IMMUNOL,15 RUE A PARE F-42023 ST ETIENNE 2 FRANCE UNIV ST ETIENNE,GRP IMMUN MUQUEUSES & AGENTS PATHOGENES F-42100 ST ETIENNE FRANCE DEPT BIOCHEM ST ETIENNE FRANCE DEPT PNEUMOL ST ETIENNE FRANCE DEPT PNEUMOL LYON FRANCE DEPT GASTROENTEROL LYON FRANCE DEPT CLIN IMMUNOL LYON FRANCE DEPT INFECT DIS LYON FRANCE
Titolo Testata:
Clinical and experimental immunology
fascicolo: 3, volume: 110, anno: 1997,
pagine: 341 - 348
SICI:
0009-9104(1997)110:3<341:HIWTLI>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; BRONCHOALVEOLAR LAVAGE CELLS; IMMUNOGLOBULIN-A ANTIBODIES; DEFICIENCY SYNDROME; STREPTOCOCCUS-PNEUMONIAE; PNEUMOCOCCAL VACCINE; BACTERIAL PNEUMONIA; IGA ANTIBODIES; AIDS PATIENTS; WOMEN;
Keywords:
HIV; LUNG; SECRETORY IGA; ANTI-HIV ANTIBODIES; ANTIBACTERIAL ANTIBODIES;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
P. Moja et al., "HUMORAL IMMUNE-RESPONSE WITHIN THE LUNG IN HIV-1 INFECTION", Clinical and experimental immunology, 110(3), 1997, pp. 341-348

Abstract

In order to study the humoral immune defences in the respiratory tract during HIV-1 infection, we measured the levels, local productions and anti-HIV and antibacterial activities of IgG and IgA in the bronchoalveolar lavage fluid (BALF) and serum of 61 adult patients with severeHIV infection and of 56 HIV- controls. Albumin was used as the serum transudation factor. The increase of immunoglobulin levels in the serum of HIV-infected patients was confirmed. The IgG level was also increased in epithelial lining fluid (ELF), whereas the total IgA level wasunchanged and secretory IgA (SIgA) level was decreased. The ELF/serumimmunoglobulin ratios suggested that the IgG present in ELF resulted mainly from transudation, in contrast to SIgA, which was synthesized locally in controls but greatly diminished in HIV-infected patients. IgG to HIV-1 could be detected in BALF of all the patients, but IgA to HIV-1 only in 30% of patients. BAL IgG reacted more consistently and with a broader array of HIV-1 antigens than did IgA. BAL IgA, when present in samples, reacted primarily with viral envelope antigens. BecauseIgA specificities to some HIV-1 antigens were detected more intensively by BAL than by serum immunoglobulins, we conclude that the mucosal immune response is distinct from that in serum. IgG antibody activity to Streptococcus pneumoniae was decreased in HIV-infected patients' sera, and IgA antibody activities to S. pneumoniae and to Pseudomonas aeruginosa were decreased in ELF in HIV-infected patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 13:15:02