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Titolo:
TOPOGRAPHICALLY CONSTRAINED AROMATIC ALPHA-AZA-AMINO ACIDS - SYNTHESIS, MOLECULAR-STRUCTURE, AND CONFORMATION OF 2 AZATIC DERIVATIVES
Autore:
TORRINI I; ZECCHINI GP; PARADISI MP; LUCENTE G; MASTROPIETRO G; GAVUZZO E; MAZZA F; POCHETTI G;
Indirizzi:
UNIV ROMA LA SAPIENZA,DIPARTIMENTO STUDI FARMACEUT I-00185 ROME ITALY UNIV ROMA LA SAPIENZA,DIPARTIMENTO STUDI FARMACEUT I-00185 ROME ITALY UNIV ROMA LA SAPIENZA,CNR,CTR STUDIO CHIM FARM I-00185 ROME ITALY UNIV AQUILA,DIPARTIMENTO CHIM I-67100 LAQUILA ITALY CNR,IST STRUTTURIST CHIM I-00016 ROME ITALY
Titolo Testata:
Tetrahedron
fascicolo: 1-2, volume: 54, anno: 1998,
pagine: 165 - 178
SICI:
0040-4020(1998)54:1-2<165:TCAAA->2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR; ANALOGS; DESIGN; PHENYLALANINE; ANTAGONISTS; PEPTIDES; RESIDUE; POTENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
I. Torrini et al., "TOPOGRAPHICALLY CONSTRAINED AROMATIC ALPHA-AZA-AMINO ACIDS - SYNTHESIS, MOLECULAR-STRUCTURE, AND CONFORMATION OF 2 AZATIC DERIVATIVES", Tetrahedron, 54(1-2), 1998, pp. 165-178

Abstract

3,4-Dihydro-2(1H)-phthalazinecarboxylic acid (azaTic) is a new conformationally restricted analogue of phenylalanine which, due to its alpha-aza-nature, should allow, in addition to the topographical control typical of the Tic residue, a definite local perturbation of the backbone conformation. Two aza Tic models, namely aza Tic-NH2 (2) and MeCO-aza Tic-NHMe (5), have been synthesized and their conformation has beendetermined and compared to that of the related Tic and azaPro models. (C) 1997 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 09:38:49