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Titolo:
ENTEROPATHY IN ZAMBIANS WITH HIV-RELATED DIARRHEA - REGRESSION MODELING OF POTENTIAL DETERMINANTS OF MUCOSAL DAMAGE
Autore:
KELLY P; DAVIES SE; MANDANDA B; VEITCH A; MCPHAIL G; ZULU I; DROBNIEWSKI F; SUMMERBELL C; LUO NP; POBEE JOM; FARTHING MJG;
Indirizzi:
ST BARTHOLOMEWS & ROYAL LONDON SCH MED & DENT,DIGEST DIS RES CTR,2 NEWARK ST LONDON E1 2AT ENGLAND ST BARTHOLOMEWS & ROYAL LONDON SCH MED & DENT,DEPT PATHOL LONDON E1 2AT ENGLAND UNIV ZAMBIA,SCH MED,DEPT MED LUSAKA ZAMBIA UNIV ZAMBIA,SCH MED,DEPT PATHOL LUSAKA ZAMBIA INNSBRUCK UNIV,INST MED CHEM & BIOCHEM A-6020 INNSBRUCK AUSTRIA INNSBRUCK UNIV,LUDWIG BOLTZMANN INST AIDS RES A-6020 INNSBRUCK AUSTRIA
Titolo Testata:
Gut
fascicolo: 6, volume: 41, anno: 1997,
pagine: 811 - 816
SICI:
0017-5749(1997)41:6<811:EIZWHD>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNODEFICIENCY-VIRUS-INFECTION; AFRICAN AIDS PATIENTS; JEJUNAL MUCOSA; INTESTINAL INFECTIONS; RAT MODEL; MORPHOLOGY; DISEASE; INFLAMMATION; MALNUTRITION; ACTIVATION;
Keywords:
SMALL INTESTINE; ENTEROPATHY; PROTOZOA; MALNUTRITION; TUMOR NECROSIS FACTOR RECEPTORS; AFRICA; AIDS;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
P. Kelly et al., "ENTEROPATHY IN ZAMBIANS WITH HIV-RELATED DIARRHEA - REGRESSION MODELING OF POTENTIAL DETERMINANTS OF MUCOSAL DAMAGE", Gut, 41(6), 1997, pp. 811-816

Abstract

Background-AIDS is characterised by small intestinal mucosal damage, but its aetiopathogenesis is poorly understood. Enteric infections in Africa differ from those in northern countries, where protozoan infections have been associated with severe enteropathy in AIDS patients. Aims T-characterise enteropathy in Zambian AIDS patients compared with local controls, and to assess relative contributions of enteric infection, nutritional impairment, and immune dysfunction. Methods-Computer aided mucosal morphometry of small intestinal biopsy specimens from 56 HIV infected Zambians with persistent diarrhoea and 26 diarrhoea free controls, followed by regression modelling. Results-Patients with HIV related diarrhoea had reduced villous height and increased crypt depthcompared with controls. There was no difference between HIV positive and negative controls. In regression models applied to AIDS mucosal measurements, villous height and crypt depth were related to nutritionalparameters and to serum soluble tumour necrosis factor receptor p55 concentration. Crypt depth was also related to lamina propria plasma cell count. Intestinal infection was found in 79%, which consisted predominantly of microsporidia in 34%, Isospora belli in 24%, and Cryptosporidium parvum in 21%, but detection of these enteropathogens was not related to severity of enteropathy. Conclusions-Nutritional and immune disturbances were associated with enteropathy, accounting for over onethird of the variation in mucosal morphometric parameters.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 17:46:17