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Titolo:
STUDIES ON THE GASTRIC-MUCOSAL MICROCIRCULATION - 2 - HELICOBACTER-PYLORI WATER-SOLUBLE EXTRACTS INDUCE PLATELET-AGGREGATION IN THE GASTRIC-MUCOSAL MICROCIRCULATION IN-VIVO
Autore:
KALIA N; JACOB S; BROWN NJ; REED MWR; MORTON D; BARDHAN KD;
Indirizzi:
UNIV SHEFFIELD,ROYAL HALLAMSHIRE HOSP,DEPT SURG & ANAESTHET SCI,GLOSSOP RD SHEFFIELD S10 2JF S YORKSHIRE ENGLAND UNIV SHEFFIELD,DEPT BIOMED SCI SHEFFIELD S10 2TN S YORKSHIRE ENGLAND ROTHERHAM DIST GEN HOSP NHS TRUST ROTHERHAM S YORKSHIRE ENGLAND
Titolo Testata:
Gut
fascicolo: 6, volume: 41, anno: 1997,
pagine: 748 - 752
SICI:
0017-5749(1997)41:6<748:SOTGM->2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHEMOTACTIC ACTIVITY; ACTIVATING FACTOR; SURFACE-PROTEINS; NEUTROPHILS; MONOCYTES; LEUKOCYTES; LEAKAGE; RAT;
Keywords:
GASTRIC MUCOSAL MICROCIRCULATION; HELICOBACTER PYLORI; FLUORESCENCE IN VIVO MICROSCOPY; PLATELET AGGREGATION; LEUKOCYTES;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
N. Kalia et al., "STUDIES ON THE GASTRIC-MUCOSAL MICROCIRCULATION - 2 - HELICOBACTER-PYLORI WATER-SOLUBLE EXTRACTS INDUCE PLATELET-AGGREGATION IN THE GASTRIC-MUCOSAL MICROCIRCULATION IN-VIVO", Gut, 41(6), 1997, pp. 748-752

Abstract

Background-The exact mechanisms by which Helicobacter pylori infection results in gastric mucosal injury are unclear. Aims-To assess in vivo whether H pylori extracts could initiate an inflammatory response inthe rat gastric mucosal microcirculation. Methods-Extracts of H pylori, Escherichia coli, or distilled water were administered topically tothe gastric mucosa of anaesthetised animals. Fluorescence in vivo microscopy assessed macromolecular leakage of labelled albumin from mucosal vessels, leucocyte adherence/rolling, and platelet activity for 90 minutes. Results-H pylori induced increases (p<0.001) in adherent platelet thrombi and circulating platelet emboli after five and 15 minutesrespectively. Adherent platelet thrombi (mean of four per field of view) remained significantly increased throughout the experiment, but circulating emboli (maximum of five at 30 minutes) decreased with time. Leucocyte adherence did not occur although early transient rolling wasobserved. An 11% increase (p<0.02) in albumin leakage occurred after five minutes only. The induction of platelet aggregation was only observed following H pylori administration. Conclusion-This in vivo study demonstrated the ability of H pylori extracts to promote platelet aggregation within gastric mucosal microvessels. Recruitment of leucocyteswas not observed. The results suggest that the early events associated with H pylori infection are platelet aggregation with perhaps subsequent leucocyte recruitment by activated platelets.

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Documento generato il 30/11/20 alle ore 07:02:15