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Titolo:
REPRESSION MECHANISMS OF THE I-A-BETA GENE OF THE MAJOR HISTOCOMPATIBILITY COMPLEX
Autore:
LLOBERAS J; SOLER C; CELADA A;
Indirizzi:
FAC BIOL,DEPT FISIOL IMMUNOL,AV DIAGONAL 645 BARCELONA 08028 SPAIN FAC BIOL,DEPT FISIOL IMMUNOL BARCELONA 08028 SPAIN UNIV BARCELONA,AUGUST PI & SUNYER FDN E-08007 BARCELONA SPAIN
Titolo Testata:
Immunobiology
fascicolo: 1-3, volume: 198, anno: 1997,
pagine: 249 - 263
SICI:
0171-2985(1997)198:1-3<249:RMOTIG>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSCRIPTION FACTOR PU.1; DNA-BINDING PROTEINS; GLUCOCORTICOID RECEPTOR; NF-Y; NEGATIVE REGULATION; X-BOX; EUKARYOTIC TRANSCRIPTION; COOPERATIVE BINDING; ANTIGEN EXPRESSION; MESSENGER-RNA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
71
Recensione:
Indirizzi per estratti:
Citazione:
J. Lloberas et al., "REPRESSION MECHANISMS OF THE I-A-BETA GENE OF THE MAJOR HISTOCOMPATIBILITY COMPLEX", Immunobiology, 198(1-3), 1997, pp. 249-263

Abstract

The mechanisms of regulation of I-AP gene expression in the murine major histocompatibility complex by transcriptional repression are reviewed. Active and passive repression mechanisms are presented. The transcription factor PU.1 actively inhibits the expression of I-AP through the binding to a DNA sequence near the Y box, a cis-element in the promoter necessary for transcription. This interaction probably interferes with the preinitiation complex assembly. NF-Y is a transcription factor that binds to the Y box and has two constituents: NF-YA (that binds weakly to DNA) and NF-YB (that increases I:he binding of NF-YA to DNA). The dbpA protein represses the expression of I-A beta by a quenching mechanism, forming a complex with NF-YA and the dbpB protein by sequestering the NF-YB protein. PI similar mechanism is observed with theglucocorticoid receptor that binds to the X-box binding proteins and inhibits their interaction with the X box. These results are examples of cross-talk between proteins, which may help us to understand the regulation of 1-A beta gene expression.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 06:54:53