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Titolo:
INFLUENCE OF PIPERACILLIN-TAZOBACTAM ON PHARMACOKINETICS OF GENTAMICIN GIVEN ONCE-DAILY
Autore:
HITT CM; PATEL KB; NICOLAU DP; ZHU Z; NIGHTINGALE CH;
Indirizzi:
MAYO MED CTR,HOSP PHARM SERV,1216 2ND ST SW ROCHESTER MN 55902 ARNOLD & MARIE SCHWARTZ COLL PHARM & HLTH SCI,DIV PHARM PRACTICE BROOKLYN NY 00000 HARTFORD HOSP,DEPT MED,DIV INFECT DIS HARTFORD CT 06115 HARTFORD HOSP,DEPT PHARM HARTFORD CT 06115
Titolo Testata:
American journal of health-system pharmacy
fascicolo: 23, volume: 54, anno: 1997,
pagine: 2704 - 2708
SICI:
1079-2082(1997)54:23<2704:IOPOPO>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
STAGE RENAL-DISEASE; CARBENICILLIN; INACTIVATION; TOBRAMYCIN; INVITRO; NETILMICIN; AMIKACIN; AMINOGLYCOSIDES; CIPROFLOXACIN; TICARCILLIN;
Keywords:
AMINOGLYCOSIDES; BETA-LACTAMASE INHIBITORS; BLOOD LEVELS; DOSAGE; DOSAGE SCHEDULES; DRUG INTERACTIONS; GENTAMICIN; HALF-LIFE; INJECTIONS; PENICILLINS; PHARMACOKINETICS; PIPERACILLIN SODIUM; TAZOBACTAM SODIUM;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
C.M. Hitt et al., "INFLUENCE OF PIPERACILLIN-TAZOBACTAM ON PHARMACOKINETICS OF GENTAMICIN GIVEN ONCE-DAILY", American journal of health-system pharmacy, 54(23), 1997, pp. 2704-2708

Abstract

The effect of piperacillin-tazobactam on the pharmacokinetics of gentamicin given once daily was studied. Healthy adult volunteers each received four drug regimens in randomized order: gentamicin 7 mg/kg i.v. once daily (1) by itself, (2) with piperacillin 4 g and tazobactam 0.5g (both as the sodium salt) every six hours i.v., (3) with piperacillin 4 g and tazobactam 0.5 g i.v. every eight hours, and (4) with piperacillin 8 g and tazobactam 1 g by continuous i.v. infusion over 24 hours. All the gentamicin doses were infused over 30 minutes two hours after piperacillin-tazobactam. Blood samples were drawn before and at the end of each gentamicin infusion and at intervals up to 12 hours after the start of each gentamicin infusion. Samples were assayed for gentamicin concentration by an enzyme multiplied immunoassay technique andfor piperacillin and tazobactam concentrations by high-performance liquid chromatography. Six women and four men completed all four drug regimens. For the gentamicin-alone regimen, the mean +/- S.D. area underthe concentration-versus-time curve was 78.06 +/- 10.28 mu g/mL . hr,the mean +/- S.D. peak concentration (30 minutes after the end of an infusion) was 20.28 +/- 2.54 mu g/mL, and the mean +/- S.D. half-life was 2.41 +/- 0.24 hours. The values for gentamicin alone did not differ significantly from those for gentamicin in any of the combination regimens. Coadministration of once-daily gentamicin and piperacillin-tazobactam in various i.v. infusion regimens did not affect the pharmacokinetics of once-daily gentamicin.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 03:48:00