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Titolo:
DISTINCT INHIBITORY EFFECTS OF SPINAL ENDOMORPHIN-1 AND ENDOMORPHIN-2ON EVOKED DORSAL HORN NEURONAL RESPONSES IN THE RAT
Autore:
CHAPMAN V; DIAZ A; DICKENSON AH;
Indirizzi:
UNIV COLL LONDON,DEPT PHARMACOL,GOWER ST LONDON WC1E 6BT ENGLAND
Titolo Testata:
British Journal of Pharmacology
fascicolo: 8, volume: 122, anno: 1997,
pagine: 1537 - 1539
SICI:
0007-1188(1997)122:8<1537:DIEOSE>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Keywords:
ANTINOCICEPTION; ENDOMORPHIN-1; ENDOMORPHIN-2; INTRATHECAL; SPINAL NEURONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
3
Recensione:
Indirizzi per estratti:
Citazione:
V. Chapman et al., "DISTINCT INHIBITORY EFFECTS OF SPINAL ENDOMORPHIN-1 AND ENDOMORPHIN-2ON EVOKED DORSAL HORN NEURONAL RESPONSES IN THE RAT", British Journal of Pharmacology, 122(8), 1997, pp. 1537-1539

Abstract

Intrathecal endomorphin-1 and endomorphin-2 (0.25-50 mu g) dose-relatedly reduced all components of electrical evoked C-fibre responses of spinal neurones. These effects were partially reversed by naloxone. Endomorphin-1, but not endomorphin-2, dose-relatedly reduced the A beta-fibre evoked responses. Peak inhibitory effects of endomorphin-1 and -2 were at 15-20 min post-administration. Thus spinal endomorphin-2 hadselective effects on noxious responses, whereas endomorphin-1 was non-selective.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 19:09:47