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Titolo:
LIPOXYGENASE INHIBITORS COUNTERACT PROTEIN-KINASE-C MEDIATED EVENTS IN HUMAN T-LYMPHOCYTE PROLIFERATION
Autore:
PAPADOGIANNAKIS N; BARBIERI B;
Indirizzi:
HUDDINGE UNIV HOSP F42,DEPT PATHOL,IMPI,KAROLINSKA INST S-14186 HUDDINGE SWEDEN
Titolo Testata:
International journal of immunopharmacology
fascicolo: 5, volume: 19, anno: 1997,
pagine: 263 - 275
SICI:
0192-0561(1997)19:5<263:LICPME>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
ARACHIDONIC-ACID METABOLISM; LEUKEMIA-CELLS; 5,8,11,14-EICOSATETRAYNOIC ACID; ANTIOXIDANT PROPERTIES; ACTIVATION PATHWAYS; 5-LIPOXYGENASE; TRANSDUCTION; EICOSANOIDS; SENSITIVITY; EXPRESSION;
Keywords:
LIPOXYGENASE INHIBITORS; PROTEIN KINASE C; T CELLS; PROLIFERATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
N. Papadogiannakis e B. Barbieri, "LIPOXYGENASE INHIBITORS COUNTERACT PROTEIN-KINASE-C MEDIATED EVENTS IN HUMAN T-LYMPHOCYTE PROLIFERATION", International journal of immunopharmacology, 19(5), 1997, pp. 263-275

Abstract

Four structurally unrelated inhibitors of lipoxygenase (LO), i.e. nordihydroguaiaretic acid (NDGA), Esculetin, AA861 and 5,8,11,14-eicosatetraynoic acid (ETYA) suppressed mitogen induced proliferation of humanperipheral blood lymphocytes in a dose-dependent manner. The degree of suppression was influenced by the type of the mitogenic stimulus. Receptor mediated stimulation, i.e. through phytohemagglutinin or the anti-CD3 antibody OKT3, was overall less susceptible, whereas proliferation initiated by direct activation of protein kinase C (PKC), i.e. through phorbol myristate acetate or indolactam V, was profoundly suppressed (up to 90%). The effect of the LO inhibitors was not due to non-specific interference with intracellular radical intermediates, because AA861 and ETYA showed no radical scavenging activity. Two PKC inhibitors, H-7 and H-8, similarly suppressed lymphocyte proliferation and showed essentially the same suppressive pattern as LO inhibitors. The results clearly indicate that LO product(s) participate in signal transduction mechanisms in T lymphocytes, possibly via stimulation of PKC activity and cell proliferation. (C) 1997 International Society for Immunopharmacology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 05:18:45