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Titolo:
DIFFERENCES IN BRONCHODILATING POTENCY OF SALBUTAMOL IN TURBUHALER(R)AS COMPARED WITH A PRESSURIZED METERED-DOSE INHALER FORMULATION IN PATIENTS WITH REVERSIBLE AIRWAY-OBSTRUCTION
Autore:
LOFDAHL CG; ANDERSSON L; BONDESSON E; CARLSSON LG; FRIBERG K; HEDNER J; HORNBLAD Y; JEMSBY P; KALLEN A; ULLMAN A; WERNER S; SVEDMYR N;
Indirizzi:
UNIV LUND HOSP,DEPT RESP MED & ALLERGOL S-22185 LUND SWEDEN GOTHENBURG UNIV,SAHLGRENSKA HOSP,DIV PULM MED S-41124 GOTHENBURG SWEDEN GOTHENBURG UNIV,SAHLGRENSKA HOSP,DIV CLIN PHARMACOL S-41124 GOTHENBURG SWEDEN HOSP TROLLHATTAN,DEPT PULM TROLLHATTAN SWEDEN HOSP UDDEVALLA,DEPT PULM UDDEVALLA SWEDEN MALMO GEN HOSP,DEPT PULM S-21401 MALMO SWEDEN VARBERG HOSP,DEPT PULM VARBERG SWEDEN ASTRO DRACO AB LUND SWEDEN
Titolo Testata:
The European respiratory journal
fascicolo: 11, volume: 10, anno: 1997,
pagine: 2474 - 2478
SICI:
0903-1936(1997)10:11<2474:DIBPOS>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
PEAK INSPIRATORY FLOW; LUNG DEPOSITION; POWDER INHALER; INHALATION DEVICE; TERBUTALINE; BUDESONIDE; ASTHMA; MDI;
Keywords:
DRY-POWDER INHALER EFFICACY; PRESSURIZED METERED-DOSE INHALER; RELATIVE POTENCY; SALBUTAMOL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
C.G. Lofdahl et al., "DIFFERENCES IN BRONCHODILATING POTENCY OF SALBUTAMOL IN TURBUHALER(R)AS COMPARED WITH A PRESSURIZED METERED-DOSE INHALER FORMULATION IN PATIENTS WITH REVERSIBLE AIRWAY-OBSTRUCTION", The European respiratory journal, 10(11), 1997, pp. 2474-2478

Abstract

Two studies are presented, with the aim of establishing the dose potency ratio for salbutamol given via Turbuhaler(R) and via a pressurizedmetered-dose inhaler (pMDI), Both studies were of a double-blind, randomized design, Outpatients with mild-to-moderate chronic reversible airway obstruction were given single doses of salbutamol administered via Turbuhaler and via pMDI, Efficacy and safety variables were measured before and during 6 h after each dose, The first study was a four-way crossover study including 12 patients. The salbutamol doses given were: 50, 100 and 2x100 mu g via Turbuhaler and 2x100 mu g via pMDI (Ventolin(R)). The study showed that 2x100 mu g of salbutamol inhaled via Turbuhaler is more potent than 2x100 mu g salbutamol inhaled via a pMDI, and that 100 mu g salbutamol via Turbuhaler is al least as potent as 2x100 mu g salbutamol inhaled via a pMDI, The second study including50 patients was a placebo-controlled five-way crossover, study, Two doses of salbutamol via Turbuhaler, 50 and 2x100 mu g, and via pMDI, 100 and 2x200 mu g, were given, There was a dose-dependent response in forced expiratory volume in one second (FEV1) for both inhalers, Adjusted for differences in baseline FEV1 values, the estimated relative dose potency for Turbuhaler versus pMDI was 1.98:1 (95% confidence interval 1.2-3.2). These studies showed that the same bronchodilating effectcan be achieved when half the dose of salbutamol given via a conventional pressurized metered-dose inhaler is given via Turbuhaler.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 14:00:10