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Titolo:
EFFECT OF CALCIUM-ION CHANNEL ANTAGONISTS ON CHORIONIC-GONADOTROPIN SECRETION
Autore:
SHARMA SC; RAO AJ;
Indirizzi:
INDIAN INST SCI,DEPT BIOCHEM BANGALORE 560012 KARNATAKA INDIA INDIAN INST SCI,CTR REPROD BIOL & MOL ENDOCRINOL BANGALORE 560012 KARNATAKA INDIA
Titolo Testata:
Biochemistry and molecular biology international
fascicolo: 5, volume: 43, anno: 1997,
pagine: 1101 - 1106
SICI:
1039-9712(1997)43:5<1101:EOCCAO>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLACENTAL MINCES INVITRO; PITUITARY GONADOTROPE; HORMONE;
Keywords:
CALCIUM ION CHANNEL; PLACENTA; VERAPAMIL; NIFEDIPINE; HCG SECRETION;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
S.C. Sharma e A.J. Rao, "EFFECT OF CALCIUM-ION CHANNEL ANTAGONISTS ON CHORIONIC-GONADOTROPIN SECRETION", Biochemistry and molecular biology international, 43(5), 1997, pp. 1101-1106

Abstract

By using calcium ion channel antagonists such as Verapamil and Nifedipine, we demonstrated that calcium ion channels are involved in human chorionic gonadotropin (hCG) secretion stimulated by gonadotropin releasing hormone (GnRH) Addition of 1 mu M Verapamil (Class II inhibitor)resulted in an inhibition of GnRH-stimulated hCG secretion by placenta without affecting basal release. However, while addition of 10 mu M Nifedipine (Class I inhibitor) resulted only in partial inhibition, significant inhibition was observed at 100 mu M concentration and above. These results suggest that calcium ion channels in placenta appear tobe similar although not identical with the channels reported in the pituitary.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 23:08:27