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Titolo:
CORTICOTROPIN-RELEASING FACTOR RECEPTORS - AN OVERVIEW
Autore:
DIETERICH KD; LEHNERT H; DESOUZA EB;
Indirizzi:
MAGDEBURG UNIV HOSP,DEPT ENDOCRINOL & METAB,LEIPZIGERSTR 44 D-39120 MAGDEBURG GERMANY NEUROCRINE BIOSCI INC SAN DIEGO CA 00000
Titolo Testata:
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
fascicolo: 2, volume: 105, anno: 1997,
pagine: 65 - 82
SICI:
0947-7349(1997)105:2<65:CFR-AO>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
FACTOR CRF RECEPTORS; ANTERIOR-PITUITARY-CELLS; CENTRAL-NERVOUS-SYSTEM; FACTOR-BINDING PROTEIN; FACTOR (CRF)-LIKE IMMUNOREACTIVITY; ADENYLATE-CYCLASE ACTIVITY; MESSENGER-RNA EXPRESSION; ADRENAL AXIS FUNCTION; RAT-BRAIN; ALZHEIMERS-DISEASE;
Keywords:
CRF; CRF RECEPTOR; CRF-BINDING PROTEIN; STRESS; CNS DISORDER;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
206
Recensione:
Indirizzi per estratti:
Citazione:
K.D. Dieterich et al., "CORTICOTROPIN-RELEASING FACTOR RECEPTORS - AN OVERVIEW", EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES, 105(2), 1997, pp. 65-82

Abstract

Corticotropin-releasing factor (CRF) is the primary physiological regulator of basal and stress-induced release of ACTH, beta-endorphin andother POMC-derived peptides from the pituitary and plays a major rolein the brain and periphery in coordinating endocrine, electrophysiological, autonomic, behavioral and immune responses to stress. In addition, recent clinical data implicate CRF in the etiology and pathophysiology in a variety of endocrine, psychiatric and neurodegenerative disorders. The various effects of CRF are mediated by two distinct CRF receptors expressed at high levels in selected brain areas, but also at different levels in several other non-neuronal tissues. This chapter provides an overview of the current knowledge about CRF receptors including tissue specificity and regulatory aspects as well as molecularbiological, biochemical and pharmacological characteristics. In addition, neuroimmune, neuroendocrine and behavioral-related implications of theCRF receptor as well as its involvement in a variety of disorders arediscussed. This review summarizes four decades of research beginning with the search for the factor that governs the release of ACTH and getting to the recent findings including the successful cloning of different receptor subtypes and the discovery of a new endogenous CRF-related ligand.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 21:38:51