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Titolo:
ALCOHOL INCREASES THE EXPRESSION OF TYPE-1, BUT NOT TYPE-2-ALPHA CORTICOTROPIN-RELEASING FACTOR(CRF) RECEPTOR MESSENGER-RIBONUCLEIC-ACID INTHE RAT HYPOTHALAMUS
Autore:
LEE S; RIVIER C;
Indirizzi:
SALK INST BIOL STUDIES,CLAYTON FDN LABS PEPTIDE BIOL,10010 N TORREY PINES RD LA JOLLA CA 92037 SALK INST BIOL STUDIES,CLAYTON FDN LABS PEPTIDE BIOL LA JOLLA CA 92037
Titolo Testata:
Molecular brain research
fascicolo: 1, volume: 52, anno: 1997,
pagine: 78 - 89
SICI:
0169-328X(1997)52:1<78:AITEOT>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; PARAVENTRICULAR NUCLEUS; ACTH-SECRETION; SUBDIAPHRAGMATIC VAGOTOMY; RNA EXPRESSION; ADRENOCORTICOTROPIN SECRETION; IMMOBILIZATION STRESS; CATECHOLAMINE NEURONS; ETHANOL WITHDRAWAL; IMMUNE CHALLENGE;
Keywords:
ALCOHOL; HYPOTHALAMUS; CORTICOTROPIN-RELEASING FACTOR (CRF) RECEPTOR; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
69
Recensione:
Indirizzi per estratti:
Citazione:
S. Lee e C. Rivier, "ALCOHOL INCREASES THE EXPRESSION OF TYPE-1, BUT NOT TYPE-2-ALPHA CORTICOTROPIN-RELEASING FACTOR(CRF) RECEPTOR MESSENGER-RIBONUCLEIC-ACID INTHE RAT HYPOTHALAMUS", Molecular brain research, 52(1), 1997, pp. 78-89

Abstract

We investigated the ability of a moderately intoxicating dose of alcohol (3 g/kg, injected i.p. 3 h earlier) to up-regulate the genetic expression of CRF receptor type 1 (CRF-R-1) and 2 (CRF-R-2 alpha) in the paraventricular nucleus (PVN) and supraoptic nucleus (SON) of the hypothalamus as well as in the amygdala. The mRNA encoding CRF-R-1 was notconstitutively expressed in the PVN or the SON but was present in theamygdala. Alcohol selectively up-regulated CRF-R-1 transcripts in thePVN. Basal levels of CRF-R-2 alpha transcripts were present in the limbic system and the ventromedial hypothalamic nucleus but were not altered by alcohol. We then determined whether the up-regulation of hypothalamic CRF-R-1 mRNA levels was functionally connected to CRF-dependent pathways. We first showed that the i.c.v. injection of CRF significantly (P < 0.01) increased CRF-R-1 but not CRF-R-2 alpha mRNA levels. We then injected the CRF antagonist, astressin, i.c.v. 30 min prior to alcohol, at a dose previously shown to completely block many CRF-dependent events in the brain, and found that it did not significantly interfere with alcohol-induced gene expression of PVN CRF-R-1. These results indicate that acute alcohol treatment selectively activates CRF-R-1in the endocrine hypothalamus and that this response does not appear to depend on the stimulation of CRF receptors. In contrast, no up-regulation of CRF-R-1 or CRF-R-2 alpha gene expression was observed in extrahypothalamic regions thought to participate in the behavioral influence of alcohol. (C) 1997 Elsevier Science B.V.

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Documento generato il 29/11/20 alle ore 06:29:01