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Titolo:
EFFECT OF GLUCOCORTICOID TREATMENT ON BIOCHEMICAL AND HORMONAL BLOOD PARAMETERS IN EARLY PREGNANT GILTS
Autore:
MADEJ A; ROMANOWICZ K; EINARSSON S; FORSBERG M; BARCIKOWSKI B;
Indirizzi:
SWEDISH UNIV AGR SCI,DEPT ANIM PHYSIOL,POB 7045 S-75007 UPPSALA SWEDEN SWEDISH UNIV AGR SCI,DEPT OBSTET & GYNAECOL S-75007 UPPSALA SWEDEN SWEDISH UNIV AGR SCI,DEPT CLIN CHEM S-75007 UPPSALA SWEDEN KIELANOWSKI INST ANIM PHYSIOL & NUTR JABLONNA POLAND
Titolo Testata:
Acta veterinaria Scandinavica
fascicolo: 3, volume: 38, anno: 1997,
pagine: 263 - 273
SICI:
0044-605X(1997)38:3<263:EOGTOB>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOSTEROID-BINDING GLOBULIN; ALKALINE-PHOSPHATASE; SERUM-CHOLESTEROL; PRIMIPAROUS SOWS; FED PCB; PIGS; CORTISOL; STRESS; PLASMA; RESPONSES;
Keywords:
PREGNANCY; FETUS; CHOLESTEROL; TRIGLYCERIOLES; ENZYMES, SERUM PROTEINS, CORTICOSTEROID-BINDING GLOBULIN; THYROXINE;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
A. Madej et al., "EFFECT OF GLUCOCORTICOID TREATMENT ON BIOCHEMICAL AND HORMONAL BLOOD PARAMETERS IN EARLY PREGNANT GILTS", Acta veterinaria Scandinavica, 38(3), 1997, pp. 263-273

Abstract

Twenty Polish Landrace gilts were grouped immediately after mating asfollows. Experiment I - Group 1 (5 gilts), control animals and Group 2 (5 gilts), injected i.m. with dexamethasone (30 mg/kg) at 12-h intervals from day 13 to day 22 of pregnancy; Experiment II - Group 3 (5 gilts), injected i.m. with corn oil from day 13 to day 22 of pregnancy and Group 4 (5 gilts), injected i.m. with hydrocortisone acetate (250 mg) at 12-h intervals from day 11 to day 20 of pregnancy. Gilts were placed in metabolic cages on day 7. On days 34-36 of pregnancy gilts were slaughtered and blood samples were collected. Serum was used for analysis of aspartate aminotransferase (S-ASAT), alanine aminotransferase(S-ALAT), alkaline phosphatase (S-ALP), S-cholesterol, S-triglycerides, S-fructosa mine, S-urea, S-total protein, and for electrophoretic fractionation of serum proteins, corticosteroid-binding globulin (CBG),cortisol, progesterone, thyroxine (T-4) and free T-4. There were no significant differences between groups in embryonic survival or in number of viable fetuses after treatment with glucocorticoids. The activity of S-ALP was lower (p<0.05) in Group 4 than in Group 3 (0.5 vs 1.2 mu kat/l). Group 4 had higher (p<0.05) levels of S-triglycerides (1.17 vs 0.73 mmol/l), S-cholesterol (5.4 vs 2.7 mmol/l), S-total protein (110.5 vs 93.3 g/l), S-albumin (56.3 vs 43.3 gill and g-globulin concentrations (18.0 vs 14.3 g/l) than Group 3. The hydrocortisone-treated gilts had lower (p<0.05) CBG (6.8 vs 21.3 nmol/l) and beta(1)-globulin (3.25 vs 5.0 g/l) concentrations than the oil-treated ones. Concentrations of T-4 were lower (p<0.05) in Groups 2 (61.3 nmo/l) and 4 (49.0 nmol/l) compared with control Groups 1 and 3 (88.2 and 97.0 nmol/l, respectively). Overall, the treatment of early pregnant gilts with hydrocortisone acetate resulted in decreased levels of S-ALP, CBG, beta(1)-globulin and T-4, and in increased levels of S-cholesterol, S-triglycerides, S-total protein, S-albumin and g-globulin. The only effect of dexamethasone was a lowering of T-4. There were no differences in free T-4, S-fructosamine or S-urea between controls and treatments. Furthermore a negative correlation between triglycerides concentrations and thenumber of embryos (r = -0.76, p<0.05) was found in control untreated and oil-treated pregnant gilts.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 01:48:24