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Titolo:
ENHANCED ENDOTHELIN-B-RECEPTOR-MEDIATED VASOCONSTRICTION OF SMALL PORCINE CORONARY-ARTERIES IN DIET-INDUCED HYPERCHOLESTEROLEMIA
Autore:
HASDAI D; MATHEW V; SCHWARTZ RS; SMITH LA; HOLMES DR; KATUSIC ZS; LERMAN A;
Indirizzi:
MAYO CLIN & MAYO FDN,DIV CARDIOVASC DIS,200 1ST ST SW ROCHESTER MN 55905 MAYO CLIN & MAYO FDN,DIV CARDIOVASC DIS & INTERNAL MED ROCHESTER MN 55905 MAYO CLIN & MAYO FDN,DEPT ANESTHESIOL ROCHESTER MN 55905 MAYO CLIN & MAYO FDN,DEPT PHARMACOL ROCHESTER MN 55905
Titolo Testata:
Arteriosclerosis, thrombosis, and vascular biology
fascicolo: 11, volume: 17, anno: 1997,
pagine: 2737 - 2743
SICI:
1079-5642(1997)17:11<2737:EEVOSP>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESISTANCE ARTERIES; ET(B) RECEPTORS; RELAXING FACTOR; L-ARGININE; ATHEROSCLEROSIS; HETEROGENEITY; ANTAGONIST; ET(A); IMMUNOREACTIVITY; MICROCIRCULATION;
Keywords:
ENDOTHELIN; SARAFOTOXIN; RECEPTORS; HYPERCHOLESTEROLEMIA; PIGS; ENDOTHELIUM;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
53
Recensione:
Indirizzi per estratti:
Citazione:
D. Hasdai et al., "ENHANCED ENDOTHELIN-B-RECEPTOR-MEDIATED VASOCONSTRICTION OF SMALL PORCINE CORONARY-ARTERIES IN DIET-INDUCED HYPERCHOLESTEROLEMIA", Arteriosclerosis, thrombosis, and vascular biology, 17(11), 1997, pp. 2737-2743

Abstract

The coronary vasoconstrictor effects of endothelins, mediated by bothendothelin ETA and ETB receptors, may be differentially altered in pathophysiological states associated with endothelial dysfunction and elevated endothelin levels. Experimental hypercholesterolemia is associated with coronary endothelial dysfunction and increased circulating endothelin concentrations. These studies were designed to test the hypothesis that experimental hypercholesterolemia is characterized by a differentially altered coronary contractile response to ETA-and ETB-receptor stimulation, in vitro. Pigs were fed either a normal or a high-cholesterol diet for 10 to 13 weeks. Changes in the intraluminal diameterof pressurized small coronary arteries (<481+/-25 mu m in diameter) to cumulative concentrations (10(-10) to 10(-6) mol/L) of endothelin-1 (ET-1), and sarafotoxin 6c (S6c), a specific ETB-receptor agonist, were measured using a video dimension analyzer. The maximal contraction attained with ET-1 was greater than with S6c in both normal (86+/-7% versus 47+/-7%, P=.001) and hypercholesterolemic (77+/-6% versus 37+/-7%, P<.001) pigs. At 10(-10) mol/L, vessels from hypercholesterolemic pigs manifested greater contraction to both ET-1 (23+/-6% versus 8+/-3%,P=.02) and S6c (17+/-5% versus 4+/-2%, P=.02). Incubation of arteriesfrom hypercholesterolemic pigs with BQ-788 (ETB-receptor antagonist),but not FR-139317 (ETA-receptor antagonist), altered the contractile response to ET-1 at 10(-10) mol/L. Removal of the endothelium abolished the difference in response to S6c between normal and hypercholesterolemic pigs. These studies demonstrate that experimental hypercholesterolemia is characterized by enhanced coronary vasoconstriction to endothelins in vitro, the mechanism of which is mediated mainly through theETB receptor. Thus, the ETB receptor has a role in regulation of coronary artery tone in both the steady-state and pathophysiological states.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 01:29:40