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Titolo:
COST-EFFECTIVENESS OF INPATIENT INITIATION OF ANTIARRHYTHMIC THERAPY FOR SUPRAVENTRICULAR TACHYCARDIAS
Autore:
SIMONS GR; EISENSTEIN EL; SHAW LJ; MARK DB; PRITCHETT ELC;
Indirizzi:
DUKE UNIV,DUKE S HOSP,MED CTR,ROOM 2000,BOX 3477 DURHAM NC 27710 DUKE UNIV,MED CTR,DIV CARDIOL DURHAM NC 27710 DUKE UNIV,MED CTR,DIV CLIN PHARMACOL DURHAM NC 27710 DUKE UNIV,MED CTR,DUKE CLIN RES INST DURHAM NC 27710
Titolo Testata:
The American journal of cardiology
fascicolo: 12, volume: 80, anno: 1997,
pagine: 1551 - 1557
SICI:
0002-9149(1997)80:12<1551:COIIOA>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC ATRIAL-FIBRILLATION; PARKINSON-WHITE SYNDROME; ACUTE MYOCARDIAL-INFARCTION; ORAL PROPAFENONE THERAPY; FLECAINIDE ACETATE; SINUS RHYTHM; FOLLOW-UP; THROMBOLYTIC THERAPY; QUINIDINE; EFFICACY;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
81
Recensione:
Indirizzi per estratti:
Citazione:
G.R. Simons et al., "COST-EFFECTIVENESS OF INPATIENT INITIATION OF ANTIARRHYTHMIC THERAPY FOR SUPRAVENTRICULAR TACHYCARDIAS", The American journal of cardiology, 80(12), 1997, pp. 1551-1557

Abstract

This study assessed the cost effectiveness of inpatient antiarrhythmic therapy initiation for supraventricular tachycardias using a metaanalysis of proarrhythmic risk and a decision analysis that compared inpatient to outpatient therapy initiation. A MEDLINE search of trials of antiarrhythmic therapy for supraventricular tachycardias was performed, and episodes of cardiac arrest, sudden or unexplained death, syncope, and sustained or unstable ventricular arrhythmias were recorded. A weighted average event rate, by sample size, was calculated and appliedto a clinical decision model of therapy initiation in which patients were either hospitalized for 72 hours or treated as outpatients. Fifty-seven drug trials involving 2,822 patients met study criteria. Based on a 72-hour weighted average event rate of 0.63% (95% confidence interval, 0.2% to 1.2%), inpatient therapy initiation cost $19,231 per year of life saved far a 60-year-old patient with a normal life expectancy. Hospitalization remained cost effective when event rates and life expectancies were varied to model hypothetical clinical scenarios. For example, cost-effectiveness ratios for a 40-year-old without structural heart disease and a 60-year-old with structural heart disease were $37,510 and $33,310, respectively, per year of life saved. Thus, a 72-hour hospitalization for antiarrhythmic therapy initiation is cost effective for most patients with supraventricular tachycardias. (C) 1997 by Excerpta Medico, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 22:58:58