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Titolo:
REGULATION OF DORSAL FATE IN THE NEURAXIS BY WNT-1 AND WNT-3A
Autore:
SAINTJEANNET JP; HE X; VARMUS HE; DAWID IB;
Indirizzi:
UNIV PENN,SCH VET MED,DEPT ANIM BIOL,3800 SPRUCE ST PHILADELPHIA PA 19104 NICHHD,GENET MOL LAB BETHESDA MD 20892 NCI,VARMUS LAB,NIH BETHESDA MD 20892
Titolo Testata:
Proceedings of the National Academy of Sciences of the United Statesof America
fascicolo: 25, volume: 94, anno: 1997,
pagine: 13713 - 13718
SICI:
0027-8424(1997)94:25<13713:RODFIT>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
XENOPUS-LAEVIS EMBRYOS; PROTO-ONCOGENE INT-1; SPEMANN ORGANIZER; SONIC-HEDGEHOG; MOUSE EMBRYO; EXPRESSION; INDUCTION; NOGGIN; GENE; DIFFERENTIATION;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
51
Recensione:
Indirizzi per estratti:
Citazione:
J.P. Saintjeannet et al., "REGULATION OF DORSAL FATE IN THE NEURAXIS BY WNT-1 AND WNT-3A", Proceedings of the National Academy of Sciences of the United Statesof America, 94(25), 1997, pp. 13713-13718

Abstract

Members of the Wnt family of signaling molecules are expressed differentially along the dorsal-ventral axis of the developing neural tube. Thus me asked whether Wnt factors are involved in patterning of the nervous system along this axis. We show that Wnt-1 and Wnt-3a, both of which are expressed in the dorsal portion of the neural tube, could synergize with the neural inducers noggin and chordin in Xenopus animal explants to generate the most dorsal neural structure, the neural crest, as determined by the expression of Krox-20, AP-2, and slug. Overexpression of Wnt-1 or Wnt-3a in the neuroectoderm of whole embryos led toa dramatic increase of slug and Krox-20-expressing cells, but the hindbrain expression of Krox-20 remained unaffected. Enlargement in the neural crest population could occur even when cell proliferation was inhibited. Wnt-5A and Wnt-8, neither of which is expressed in the dorsalneuroectoderm, failed to induce neural crest markers. Overexpression of glycogen synthase kinase 3, known to antagonize Wnt signaling, blocked the neural-crest-inducing activity of Wnt-3a in animal explants and inhibited neural crest formation in whole embryos. We suggest that Wnt-1 and Wnt-3a have a role in patterning the neural tube along its dorsoventral axis and function in the differentiation of the neural crest.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 21:19:30