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Titolo:
HISTOPATHOLOGY AND PATHOBIOLOGY OF HEPATOTROPIC VIRUS-INDUCED LIVER-INJURY
Autore:
HUANG SN; CHEN TC; TSAI SL; LIAW YF;
Indirizzi:
CHANG GUNG MEM HOSP,LIVER RES UNIT,199 TUNG HWA N RD TAIPEI 10591 TAIWAN CHANG GUNG MEM HOSP,LIVER RES UNIT TAIPEI 10591 TAIWAN CHANG GUNG MEM HOSP,DEPT PATHOL TAIPEI 10591 TAIWAN NATL TAIWAN UNIV,COLL MED TAIPEI 10018 TAIWAN UNIV TORONTO,SUNNYBROOK HLTH SCI CTR,DEPT PATHOL N YORK ON CANADA
Titolo Testata:
Journal of gastroenterology and hepatology
fascicolo: 9-10, volume: 12, anno: 1997,
pagine: 195 - 217
SICI:
0815-9319(1997)12:9-10<195:HAPOHV>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEPATITIS-B VIRUS; CHRONIC ACTIVE HEPATITIS; CHRONIC VIRAL-HEPATITIS; TUMOR-NECROSIS-FACTOR; FIBROSING CHOLESTATIC HEPATITIS; POLYMERASE CHAIN-REACTION; CYTOTOXIC T-LYMPHOCYTES; IN-SITU HYBRIDIZATION; CELL-MEDIATED CYTOTOXICITY; NUMERICAL SCORING SYSTEM;
Keywords:
IMMUNOPATHOGENESIS; IMMUNOPATHOLOGY; MULTIPLE VIRAL INFECTIONS; PATHOBIOLOGY OF VIRAL HEPATITIS; PATHOLOGY OF VIRAL HEPATITIS; VIRAL HEPATITIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
213
Recensione:
Indirizzi per estratti:
Citazione:
S.N. Huang et al., "HISTOPATHOLOGY AND PATHOBIOLOGY OF HEPATOTROPIC VIRUS-INDUCED LIVER-INJURY", Journal of gastroenterology and hepatology, 12(9-10), 1997, pp. 195-217

Abstract

The present report concerns current knowledge regarding immunopathogenesis that can be applied in the interpretation of histopathological changes in acute and chronic viral hepatitis. The histopathological features of viral hepatitis have not been changed and light microscopic examination remains essential for making a diagnosis and classificationof chronic hepatitis and for the provision of objective parameters ongrading and staging. However, new understanding and knowledge of viral pathogenesis, host immune responses, the biological behaviour of thecausative viral agents and, in particular, viral interference in multiple hepatotropic viral infections must be taken into consideration inthe interpretation of histopathological and immunopathological findings of liver tissues. This report also presents some histopathological analyses on multiple hepatotropic viral infections. It can be concluded that the diagnostic histological criteria for acute hepatitis remainapplicable in such settings. However, the cause of acute flare up in chronic hepatitis could not be determined without clinical, virological and serological information. Routine histopathology cannot distinguish a new infection from an acute exacerbation due to a high level of viral replication or mutant, virus. A repertoire of immunocytochemical stainings for viral antigens is helpful, bur camion must be exercised in suggesting a specific viral aetiology due to the fact that suppression of pre-existing viral antigens can be pronounced when the new or concurrent infection is hepatitis C virus related.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 22:34:47