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Titolo:
TACHYKININ RECEPTORS ON MOTONEURONS IN THE SPINAL-CORDS OF NEONATAL RATS, GERBILS AND HAMSTERS
Autore:
GUO JZ; YOSHIOKA K; HOSOKI R; OTSUKA M;
Indirizzi:
GEORGE WASHINGTON UNIV,MED CTR,DEPT PHARMACOL,2300 EYE ST NW,ROOM 640WASHINGTON DC 20037 TOKYO MED & DENT UNIV,FAC MED,DEPT PHARMACOL TOKYO 113 JAPAN TOKYO MED & DENT UNIV,FAC MED,DIV SCI LAB TOKYO 113 JAPAN
Titolo Testata:
Neuropeptides
fascicolo: 5, volume: 31, anno: 1997,
pagine: 495 - 501
SICI:
0143-4179(1997)31:5<495:TROMIT>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUBSTANCE-P; NONPEPTIDE ANTAGONIST; NK1 RECEPTOR; PHARMACOLOGICAL PROPERTIES; SPECIES VARIANTS; NEWBORN RAT; SEPTIDE; POTENT; NEUROTRANSMITTER; STIMULATION;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
J.Z. Guo et al., "TACHYKININ RECEPTORS ON MOTONEURONS IN THE SPINAL-CORDS OF NEONATAL RATS, GERBILS AND HAMSTERS", Neuropeptides, 31(5), 1997, pp. 495-501

Abstract

As a step to clarify the profiles of tachykinin receptors in the mammalian central nervous system, we examined the effects of various tachykinin receptor agonists and antagonists on motoneurons in isolated spinal cord preparations from rats, gerbils and hamsters. After treatmentwith tetrodotoxin, potential changes were recorded extracellularly from lumbar ventral roots at 27 degrees C. Bath-application of tachykinin NK1, NK3 receptor agonists produced depolarizing responses of ventral roots, In contrast, selective NK2 agonists exerted no or only marginal depolarizing action. Neurokinin A (NKA), however, exerted a distinct depolarizing action on motoneurons. Tachykinin NK1 receptor antagonists antagonized the actions of SPOMe and NKA in a competitive manner. The present results suggest that tachykinin NK1 and NK3 receptors are present on spinal motoneurons of newborn rats, gerbils and hamsters, and that NKA acts on the NK1 receptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 10:01:47