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Titolo:
PROPHYLACTIC ADMINISTRATION OF A COMPLEMENTARITY-DETERMINING REGION DERIVED FROM A NEUTRALIZING MONOCLONAL-ANTIBODY IS EFFECTIVE AGAINST RESPIRATORY SYNCYTIAL VIRUS-INFECTION IN BALB C MICE/
Autore:
BOURGEOIS C; BOUR JB; AHO LS; POTHIER P;
Indirizzi:
FAC MED DIJON,LAB MICROBIOL MED & MOL,BLD JEANNE DARC F-21033 DIJON FRANCE CHUR BOCAGE,SERV EPIDEMIOL & HYG HOSP F-21034 DIJON FRANCE
Titolo Testata:
Journal of virology
fascicolo: 1, volume: 72, anno: 1998,
pagine: 807 - 810
SICI:
0022-538X(1998)72:1<807:PAOACR>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
COTTON RATS; IMMUNE GLOBULIN; FUSION PROTEIN; YOUNG-CHILDREN; IMMUNOTHERAPY; INFANTS; IMMUNOPROPHYLAXIS; PEPTIDES; TRACT; IGG;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
C. Bourgeois et al., "PROPHYLACTIC ADMINISTRATION OF A COMPLEMENTARITY-DETERMINING REGION DERIVED FROM A NEUTRALIZING MONOCLONAL-ANTIBODY IS EFFECTIVE AGAINST RESPIRATORY SYNCYTIAL VIRUS-INFECTION IN BALB C MICE/", Journal of virology, 72(1), 1998, pp. 807-810

Abstract

Immunotherapy with antibodies against respiratory syncytial virus (RSV) is a treatment option given the absence of any vaccine or other available satisfactory treatment. We selected one of our monoclonal antibodies, RS-348, that is highly neutralizing. We showed that a single peptide (PEP3H) derived from complementarity-determining region 3 (CDR3)of its heavy chain was capable of neutralizing the virus in vitro. When intranasally administered 24 h before challenge, this peptide protected BALB/c mice against RSV lung infection. These results indicate that a single CDR can be effective against RSV infection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 16:27:51