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Titolo:
INFECTIOUS CELLULAR LOAD IN HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 (HIV-1)-INFECTED INDIVIDUALS AND SUSCEPTIBILITY OF PERIPHERAL-BLOOD MONONUCLEAR-CELLS FROM THEIR EXPOSED PARTNERS TO NON-SYNCYTIUM-INDUCING HIV-1AS MAJOR DETERMINANTS FOR HIV-1 TRANSMISSION IN HOMOSEXUAL COUPLES
Autore:
BLAAK H; VANTWOUT AB; BROUWER M; CORNELISSEN M; KOOTSTRA NA; ALBRECHTVANLENT N; KEET RPM; GOUDSMIT J; COUTINHO RA; SCHUITEMAKER H;
Indirizzi:
NETHERLANDS RED CROSS,BLOOD TRANSFUS SERV,CENT LAB,DEPT CLIN VIROIMMUNOL,PLESMANLAAN 125 NL-1066 CX AMSTERDAM NETHERLANDS NETHERLANDS RED CROSS,BLOOD TRANSFUS SERV,CENT LAB,DEPT CLIN VIROIMMUNOL NL-1066 CX AMSTERDAM NETHERLANDS UNIV AMSTERDAM,ACAD MED CTR,EXPT & CLIN IMMUNOL LAB NL-1012 WX AMSTERDAM NETHERLANDS UNIV AMSTERDAM,ACAD MED CTR,DEPT HUMAN RETROVIROL NL-1012 WX AMSTERDAM NETHERLANDS MUNICIPAL HLTH SERV,DEPT PUBL HLTH AMSTERDAM NETHERLANDS
Titolo Testata:
Journal of virology
fascicolo: 1, volume: 72, anno: 1998,
pagine: 218 - 224
SICI:
0022-538X(1998)72:1<218:ICLIHT>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
VERTICAL TRANSMISSION; BIOLOGICAL PHENOTYPE; ZIDOVUDINE TREATMENT; VIRAL PHENOTYPE; PROGRESSION; MACAQUES; RECEPTOR; MEN; POPULATIONS; ANTIBODIES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
H. Blaak et al., "INFECTIOUS CELLULAR LOAD IN HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 (HIV-1)-INFECTED INDIVIDUALS AND SUSCEPTIBILITY OF PERIPHERAL-BLOOD MONONUCLEAR-CELLS FROM THEIR EXPOSED PARTNERS TO NON-SYNCYTIUM-INDUCING HIV-1AS MAJOR DETERMINANTS FOR HIV-1 TRANSMISSION IN HOMOSEXUAL COUPLES", Journal of virology, 72(1), 1998, pp. 218-224

Abstract

To study risk factors for homosexual transmission of human immunodeficiency virus type 1 (HIV-1), we compared 10 monogamous homosexual couples between whom transmission of HIV-1 had occurred,vith 10 monogamoushomosexual couples between whom HIV-1 transmission had not occurred despite high-risk sexual behavior. In the group of individuals who did not transmit virus, peripheral cellular infectious load was lower and the CD4(+) T-cell counts were higher than in the group of transmitters. HIV-1 RNA levels in serum did not differ between transmitters and nontransmitters. Compared with peripheral blood mononuclear cells (PBMC)from normal healthy blood donors, 8 of 10 nonrecipients and only 3 of8 recipients had PBMC with reduced susceptibility to in vitro infection with non-syncytium-inducing (NSI) HIV-1 variants isolated from either their respective partners or an unrelated individual. No differencein susceptibility was observed for infection with a syncytium-inducing variant. Among the individuals who had PBMC with reduced susceptibility, five nonrecipients and one recipient had PBMC that were equally or even less susceptible to NSI variants than PBMC that had low susceptibility and that were derived from healthy blood donors that were heterozygous for a 32-bp deletion in the CCR5 gene (CCR5 Delta 32). Three of these individuals (all nonrecipients) had a CCR5 Delta 32 heterozygous genotype themselves, confirming an association between low susceptibility to NSI variants and CCR5 Delta 32 heterozygosity. All three recipients with less susceptible PBMC had partners with a high infectious cellular load; inversely, both nonrecipients with normally susceptible PBMC had partners with a very low infectious cellular load. These results suggest that a combination of susceptibility of target cells and inoculum size upon homosexual exposure largely determines whether HIV-1 infection is established.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 15:41:16