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Titolo:
PHYLOGENY OF THE GENUS FLAVIVIRUS
Autore:
KUNO G; CHANG GJJ; TSUCHIYA KR; KARABATSOS N; CROPP CB;
Indirizzi:
CTR DIS CONTROL & PREVENT,ARBOVIRUS DIS BRANCH,DIV VECTOR BORNE INFECT DIS,NATL CTR INFECT DIS FT COLLINS CO 80522
Titolo Testata:
Journal of virology
fascicolo: 1, volume: 72, anno: 1998,
pagine: 73 - 83
SICI:
0022-538X(1998)72:1<73:POTGF>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
TICK-BORNE ENCEPHALITIS; NUCLEOTIDE-SEQUENCES; ANTIGENIC RELATIONSHIPS; VIRUS; CLASSIFICATION; IDENTIFICATION; MEMBER; ENCEPHALOMYELITIS; SEROCOMPLEX; DISTINCT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
52
Recensione:
Indirizzi per estratti:
Citazione:
G. Kuno et al., "PHYLOGENY OF THE GENUS FLAVIVIRUS", Journal of virology, 72(1), 1998, pp. 73-83

Abstract

We undertook a comprehensive phylogenetic study to establish the genetic relationship among the viruses of the genus Flavivirus and to compare the classification based on molecular phylogeny,vith the existing serologic method. By using a combination of quantitative definitions (bootstrap support level and the pairwise nucleotide sequence identity), the viruses could be classified into clusters, clades, and species. Our phylogenetic study revealed for the first time that from the putative ancestor two branches, non-vector and vector-borne virus clusters,evolved and from the latter cluster emerged tick-borne and mosquito-borne virus clusters. Provided that the theory of arthropod associationbeing an acquired trait was correct, pairwise nucleotide sequence identity among these three clusters provided supporting data for a possibility that the non-vector cluster evolved first, followed by the separation of tick-borne and mosquito-borne virus clusters in that order. Clades established in our study correlated significantly with existing antigenic complexes. We also resolved many of the past taxonomic problems by establishing phylogenetic relationships of the antigenically unclassified viruses,vith the well-established viruses and by identifying synonymous viruses.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 15:13:20