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Titolo:
RABBIT IGG DISTRIBUTION IN SKIN, SPINAL-CORD AND DRG FOLLOWING SYSTEMIC INJECTION IN RAT
Autore:
TONRA JR; MENDELL LM;
Indirizzi:
SUNY STONY BROOK,DEPT NEUROBIOL & BEHAV STONY BROOK NY 11794 SUNY STONY BROOK,DEPT NEUROBIOL & BEHAV STONY BROOK NY 11794
Titolo Testata:
Journal of neuroimmunology
fascicolo: 1-2, volume: 80, anno: 1997,
pagine: 97 - 105
SICI:
0165-5728(1997)80:1-2<97:RIDISS>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVE GROWTH-FACTOR; CHARGE-SELECTIVE PERMEABILITY; DERMO-EPIDERMAL JUNCTION; ADULT SENSORY NEURONS; BASEMENT-MEMBRANE; POSTNATAL-DEVELOPMENT; MYELINATED NOCICEPTORS; GANGLION-CELLS; ANIONIC SITES; NEONATAL RAT;
Keywords:
BLOOD-BRAIN BARRIER; DERMO-EPIDERMAL JUNCTION; NERVE GROWTH FACTOR; ANTI-NGF;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
J.R. Tonra e L.M. Mendell, "RABBIT IGG DISTRIBUTION IN SKIN, SPINAL-CORD AND DRG FOLLOWING SYSTEMIC INJECTION IN RAT", Journal of neuroimmunology, 80(1-2), 1997, pp. 97-105

Abstract

In order to determine the distribution of antibodies such as anti-NGFfollowing systemic injection in neonates, immunocytochemical techniques were used to examine the localization of rabbit IgG in rat skin, DRG, and spinal cord after treatments with normal rabbit serum or purified rabbit IgG. Daily subcutaneous injections beginning on postnatal day 2 or on day 15 were given for three days. On the fourth day the animals were sacrificed and tissues were processed for rabbit IgG-IR. In the dorsal and ventral spinal cord, staining intensities suggest a substantial increase in the blood-brain barrier during the first two weeksafter birth. Staining intensity in the epidermis of the glabrous skinfrom the hindpaw was substantially lower than in the adjacent dermis. In addition, IgG infrequently accumulated intracellularly in intensely stained patches in the epidermis. IgG was also able to reach relatively high intracellular concentrations in a small number of sensory neurons. The IgG staining pattern in the skin was similar when anti-NGF itself was administered to the animals. The results are discussed in the context of the effects of anti-NGF on the development of nociceptiveafferents. (C) 1997 Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 06:12:37