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Titolo:
GENETIC-ANALYSIS OF INFLAMMATION, CYTOKINE MESSENGER-RNA EXPRESSION AND DISEASE COURSE OF RELAPSING EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS IN DA RATS
Autore:
LORENTZEN JC; ANDERSSON M; ISSAZADEH S; DAHLMAN I; LUTHMAN H; WEISSERT R; OLSSON T;
Indirizzi:
KAROLINSKA HOSP,DEPT MED,RHEUMATOL UNIT S-17176 STOCKHOLM SWEDEN KAROLINSKA HOSP,DEPT NEUROL,MOL MED UNIT S-10401 STOCKHOLM SWEDEN KAROLINSKA HOSP,DEPT MOL MED,ROLF LUFT CTR DIABET RES S-10401 STOCKHOLM SWEDEN
Titolo Testata:
Journal of neuroimmunology
fascicolo: 1-2, volume: 80, anno: 1997,
pagine: 31 - 37
SICI:
0165-5728(1997)80:1-2<31:GOICME>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; CENTRAL-NERVOUS-SYSTEM; MAJOR HISTOCOMPATIBILITY COMPLEX; MESSENGER-RNA EXPRESSION; MULTIPLE-SCLEROSIS; MONOCLONAL-ANTIBODIES; FACTOR-BETA; LEWIS RATS; SUSCEPTIBILITY; LINKAGE;
Keywords:
MULTIPLE SCLEROSIS; MHC; INTERFERON-GAMMA; IL-10; TGF-BETA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
J.C. Lorentzen et al., "GENETIC-ANALYSIS OF INFLAMMATION, CYTOKINE MESSENGER-RNA EXPRESSION AND DISEASE COURSE OF RELAPSING EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS IN DA RATS", Journal of neuroimmunology, 80(1-2), 1997, pp. 31-37

Abstract

Genetic analysis of experimental autoimmune encephalomyelitis (EAE) can provide clues to the etiology of multiple sclerosis (MS). Identifying the susceptibility genes of DA rats may be particularly rewarding since they are prone to develop a remarkably MS-like chronic and demyelinating disease. As a first step in this direction, we investigated the role of DA genes within and outside the major histocompatibility complex (MHC) for susceptibility to severe protracted and relapsing EAE (SPR-EAE). This form of EAE developed in DA rats but not in LEW, ACI and BN rats after immunization with syngeneic spinal cord and complete Freund's adjuvant. Studies of crosses between DA and BN rats revealed that non-MHC genes determine susceptibility to SPR-EAE. A role for MHC-genes was also established using MHC-congenic rat strains, in which the DA MHC haplotype (av1) associated with relapsing EAE. Again, non-MHCgenes were decisive since a high incidence of SPR-EAE only occurred in rats with DA non-MHC genes. Analysis of cytokine mRNA expression andinfiltrating cells in the spinal cords of congenic strains revealed that the av1 haplotype associated with a high CD4/CD8 ratio and expression of mRNA for interferon-gamma (IFN-gamma), but not for transforminggrowth factor-beta (TGF-beta) or interleukin-10 (IL-10). In contrast,the other MHC haplotypes (h, l, u) associated with low CD4/CD8 ratiosand mRNA expression for TGF-beta and IL-10, but not for IFN-gamma. DAnon-MHC genes determined the intensity of inflammation since the number of cells expressing MHC class II, CD4 and interleukin-2 receptor (IL-2R) was higher in DA rats than in LEW.1AVl and PVG.1AVl rats which also carry the av1 haplotype. We conclude that the MHC haplotype of DA rats favors a prolonged proinflammatory autoimmune response associatedwith relapses, while the DA background intensifies inflammation correlating with a high incidence of relapsing disease. (C) 1997 Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 05:04:14