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Titolo:
ANTHELMINTICS - A COMPARATIVE REVIEW OF THEIR CLINICAL-PHARMACOLOGY
Autore:
DESILVA N; GUYATT H; BUNDY D;
Indirizzi:
UNIV OXFORD,DEPT ZOOL,WELLCOME TRUST CTR EPIDEMIOL INFECT DIS,S PARKSRD OXFORD OX1 3PS ENGLAND UNIV OXFORD,DEPT ZOOL,WELLCOME TRUST CTR EPIDEMIOL INFECT DIS OXFORD OX1 3PS ENGLAND
Titolo Testata:
Drugs
fascicolo: 5, volume: 53, anno: 1997,
pagine: 769 - 788
SICI:
0012-6667(1997)53:5<769:A-ACRO>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
CUTANEOUS LARVA MIGRANS; TERM FOLLOW-UP; WUCHERERIA-BANCROFTI FILARIASIS; COMMUNITY-BASED DISTRIBUTION; RANDOMIZED CONTROLLED TRIAL; HUMAN CYSTIC ECHINOCOCCOSIS; SOIL-TRANSMITTED NEMATODES; CHEMOTHERAPY-BASED CONTROL; DOSE MEBENDAZOLE THERAPY; HUMAN HYDATID-DISEASE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
241
Recensione:
Indirizzi per estratti:
Citazione:
N. Desilva et al., "ANTHELMINTICS - A COMPARATIVE REVIEW OF THEIR CLINICAL-PHARMACOLOGY", Drugs, 53(5), 1997, pp. 769-788

Abstract

Virtually all the important helminth infections in humans can be treated with one of 5 anthelmintics currently in use: albendazole, mebendazole, diethylcarbamazine, ivermectin and praziquantel. These drugs arevital not only for the treatment of individual infections, but also useful in controlling transmission of the more common infections. This article reviews briefly the pharmacology of these 5 drugs, and then discusses current issues in the use of anthelmintics in the treatment and/or control of soil-transmitted nematode infections, filariasis, onchocerciasis, schistosomiasis (and other trematode infections), neurocysticercosis and hydatidosis. Mebendazole and albendazole are most effective against intestinal nematodes, but are contraindicated during the first trimester of pregnancy. The efficacy of prolonged therapy with these 2 drugs for treatment of larval cestode infections has not yet been established. Diethylcarbamazine is widely used to treat and controllymphatic filariasis, but adverse effects related to death of microfilariae or damage to adult worms may be marked. While ivermectin has been used in the treatment of patients with onchocerciasis, it is also undergoing investigation against lymphatic filariae. Praziquantel, usedto treat schistosome infections, is also effective in other trematodeinfections and adult cestode infections.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 04:05:47